CAJ | 학술논문

目的：优选羟丙基-β-环糊精（HP-β-CD）包合超临界提取的芪葛口服液挥发油的制备工艺参数。方法采用正交实验法，以包合物中挥发油的包合率为指标，对胶体磨应用于HP-β-CD包合芪葛口服液挥发油进行考察。结果优选得到最佳工艺为：芪葛口服液挥发油与HP-β-CD比例为1∶12（mL∶g），HP-β-CD和水的重量比为1∶3（g∶g），包合温度为25℃，包合时间为10 min。结论优选的工艺包合率高、简便可行。
목적：우선간병기-β-배호정（HP-β-CD）포합초림계제취적기갈구복액휘발유적제비공예삼수。방법채용정교실험법，이포합물중휘발유적포합솔위지표，대효체마응용우HP-β-CD포합기갈구복액휘발유진행고찰。결과우선득도최가공예위：기갈구복액휘발유여HP-β-CD비례위1∶12（mL∶g），HP-β-CD화수적중량비위1∶3（g∶g），포합온도위25℃，포합시간위10 min。결론우선적공예포합솔고、간편가행。
Objective To optimize the hydroxypropyl-β-cyclodextrin(HP-β-CD)inclusion procedure for the essencial oil from Qige oralliquid with supercritical fluid extraction. Methods The study was carried out using the orthogonal design and the process conditions were screened by determining the inclusion rate of essencial oil in the high shearing mixer method. Results The optimum preparation conditions for inclusion were established as follows:the proportion of essencial oil and HP-β-CD was 1∶12(mL∶g),HP-β-CD and water was 1∶3(g∶g),the inclusion temperature was at 25 ℃and inclusion time was 10 minutes. Conclusion The complex prepared under the optimized condition is stable and has a highest inclusion rate.