中国处方药
中國處方藥
중국처방약
CHINA PRESCRIPTION DRUG
2015年
6期
12-13
,共2页
普罗帕酮%胺碘酮%急性心肌梗死%心房颤动%联合用药
普囉帕酮%胺碘酮%急性心肌梗死%心房顫動%聯閤用藥
보라파동%알전동%급성심기경사%심방전동%연합용약
Propafenone%Amiodarone%Acute Myocardial Infarction%Atrial Fibrillation%Combination Therapy
目的：探讨普罗帕酮联合胺碘酮治疗老年急性心肌梗死（AMI）合并心房颤动（AF）的疗效及不良反应。方法选取2008年1月～2014年3月收治的AMI合并有AF的老年患者96例，随机分成对照组和试验组，每组48例。对照组患者应用胺碘酮治疗，试验组患者采用普罗帕酮联合胺碘酮治疗。分析比较两组患者接受治疗后心房颤动转复效果、窦性心律维持率及不良反应情况。结果0～6 h及6～12 h内试验组患者AF转复率高于对照组（χ2＝6.400、8.491，P＜0.05），18～24 h内对照组高于试验组（χ2＝5.897，P＜0.05），12～18 h内和总转复率差异无统计学意义（χ2＝2.987、1.200，P＞0.05）。试验组窦性心律维持有效率明显高于对照组，差异具有统计学意义（χ2＝20.364，P＜0.05）。试验组不良反应率低于对照组（χ2＝7.940，P＜0.05）。结论普罗帕酮联合胺碘酮治疗AMI并发AF效果和安全性优于单独给予胺碘酮。
目的：探討普囉帕酮聯閤胺碘酮治療老年急性心肌梗死（AMI）閤併心房顫動（AF）的療效及不良反應。方法選取2008年1月～2014年3月收治的AMI閤併有AF的老年患者96例，隨機分成對照組和試驗組，每組48例。對照組患者應用胺碘酮治療，試驗組患者採用普囉帕酮聯閤胺碘酮治療。分析比較兩組患者接受治療後心房顫動轉複效果、竇性心律維持率及不良反應情況。結果0～6 h及6～12 h內試驗組患者AF轉複率高于對照組（χ2＝6.400、8.491，P＜0.05），18～24 h內對照組高于試驗組（χ2＝5.897，P＜0.05），12～18 h內和總轉複率差異無統計學意義（χ2＝2.987、1.200，P＞0.05）。試驗組竇性心律維持有效率明顯高于對照組，差異具有統計學意義（χ2＝20.364，P＜0.05）。試驗組不良反應率低于對照組（χ2＝7.940，P＜0.05）。結論普囉帕酮聯閤胺碘酮治療AMI併髮AF效果和安全性優于單獨給予胺碘酮。
목적：탐토보라파동연합알전동치료노년급성심기경사（AMI）합병심방전동（AF）적료효급불량반응。방법선취2008년1월～2014년3월수치적AMI합병유AF적노년환자96례，수궤분성대조조화시험조，매조48례。대조조환자응용알전동치료，시험조환자채용보라파동연합알전동치료。분석비교량조환자접수치료후심방전동전복효과、두성심률유지솔급불량반응정황。결과0～6 h급6～12 h내시험조환자AF전복솔고우대조조（χ2＝6.400、8.491，P＜0.05），18～24 h내대조조고우시험조（χ2＝5.897，P＜0.05），12～18 h내화총전복솔차이무통계학의의（χ2＝2.987、1.200，P＞0.05）。시험조두성심률유지유효솔명현고우대조조，차이구유통계학의의（χ2＝20.364，P＜0.05）。시험조불량반응솔저우대조조（χ2＝7.940，P＜0.05）。결론보라파동연합알전동치료AMI병발AF효과화안전성우우단독급여알전동。
Objective To explore the treatment of elderly patients with acute myocardial infection(AMI)and atrial fibrillation(AF)by propafenone and amiodarone and analysis it efficacy and adverse reactions. Methods Ninety six elderly patients with AMI merger with AF in our hospital from January 2008 to March 2014 were collected and randomly divided into control and experimental groups,each group of 48. The control group were treated with amiodarone and the experimental group were treated with propafenone and amiodarone. Cardioversion of atrial fibrillation,sinus rhythm maintenance rate and adverse reactions of the two groups were analyzed and compared after treatment. Results The AF cardioversion rate of experimental group was significantly higher than that of control group in 0~6 h and 6~12 h(χ2=6.400、8.491,P<0.05),control group was significantly higher than the treatment group in 18~24 h(χ2=5.897,P<0.05),There were no statistical differences in the cardioversion rate of 12~18 h and total(χ2=2.987、1.200,P>0.05). Sinus rhythm maintenance rate of experimental group was significantly higher than control group(χ2 = 20.364,P< 0.05). Adverse reaction rates of the experimental group was significantly lower than the control group(χ2=7.940,P<0.05). Conclusion Treatment of AMI and AF by propafenone and amiodarone are more superior and safety than amiodarone alone,is worth in on promoting the application clinically.
