中国处方药
中國處方藥
중국처방약
CHINA PRESCRIPTION DRUG
2015年
6期
11-11,12
,共2页
糖尿病肾病%坎地沙坦%卡托普利
糖尿病腎病%坎地沙坦%卡託普利
당뇨병신병%감지사탄%잡탁보리
Diabetic nephropathy%Candesartan%Captopril
目的：探讨坎地沙坦联合卡托普利治疗糖尿病肾病（DN）的疗效。方法选取2011年1月～2014年12月收治的DN患者56例作为观察对象，并随机将DN患者分为观察组与对照组，各28例。对照组应用卡托普利进行治疗，观察组在对照组的基础上加用坎地沙坦进行治疗，比较两组的疗效。结果治疗后两组的血压（SBP、DBP）、尿蛋白排泄率（UAER）及肾小球滤过率（GFR）均显著降低，且观察组低于对照组，组间差异均具统计学意义（P＜0.05）；两组的不良反应率无统计学差异（P＞0.05）。结论坎地沙坦联合卡托普利治疗DN能够有效控制患者的血压水平，减少尿蛋白排泄，减轻肾损害，且不良反应较少。
目的：探討坎地沙坦聯閤卡託普利治療糖尿病腎病（DN）的療效。方法選取2011年1月～2014年12月收治的DN患者56例作為觀察對象，併隨機將DN患者分為觀察組與對照組，各28例。對照組應用卡託普利進行治療，觀察組在對照組的基礎上加用坎地沙坦進行治療，比較兩組的療效。結果治療後兩組的血壓（SBP、DBP）、尿蛋白排洩率（UAER）及腎小毬濾過率（GFR）均顯著降低，且觀察組低于對照組，組間差異均具統計學意義（P＜0.05）；兩組的不良反應率無統計學差異（P＞0.05）。結論坎地沙坦聯閤卡託普利治療DN能夠有效控製患者的血壓水平，減少尿蛋白排洩，減輕腎損害，且不良反應較少。
목적：탐토감지사탄연합잡탁보리치료당뇨병신병（DN）적료효。방법선취2011년1월～2014년12월수치적DN환자56례작위관찰대상，병수궤장DN환자분위관찰조여대조조，각28례。대조조응용잡탁보리진행치료，관찰조재대조조적기출상가용감지사탄진행치료，비교량조적료효。결과치료후량조적혈압（SBP、DBP）、뇨단백배설솔（UAER）급신소구려과솔（GFR）균현저강저，차관찰조저우대조조，조간차이균구통계학의의（P＜0.05）；량조적불량반응솔무통계학차이（P＞0.05）。결론감지사탄연합잡탁보리치료DN능구유효공제환자적혈압수평，감소뇨단백배설，감경신손해，차불량반응교소。
Objective To investigate the efficacy of captopril combined with candesartan in the treatment of diabetic nephropathy(DN). Methods 56 cases of DN patients were randomly divided into observation group and control group,28 cases in each. The control group received captopril treatment,and observation group received candesartan treatment. Then the efficacy of the two groups were compared. Results After treatment,the blood pressure(SBP, DBP),UAER and GFR of the two groups were significantly reduced,and the observation group was significantly lower than that of the control group(P< 0.05);adverse reaction rates between the two groups were no significant difference(P > 0.05). Conclusion Candesartan combined with captopril in treatment of DN can effectively control blood pressure,reduce urinary protein excretion,reduce kidney damage,and have fewer adverse reactions.
