CAJ | 학술논문

目的：初步考察便携式人工心肺辅助装置的在体性能。方法应用肝素涂层中空纤维氧合技术与磁悬浮离心泵装置整合构建小型化、便携式心肺辅助装置。40 kg实验羊（ n＝6）在全麻下第五肋间左前外侧切口，分别置入右心房插管连接至人工心肺辅助装置流入道，降主动脉插管连接至装置流出道开始转流，4．0 L／min运转12 h，于转流前和转流后每2 h检测装置流入道及流出道血氧饱和度，氧分压，二氧化碳分压等，计算装置氧合效率。取静脉血检测游离血红蛋白检含量评价装置溶血性能并检测血小板激活率。结果12 h中，装置流出道氧饱和度保持98％以上，氧合效率稳定。4．0 L／min流量运行12 h，游离血红蛋白含量均在20 g／L以下，血小板激活均小于8％。结论应用肝素涂层中空纤维氧合器与磁悬浮离心血泵构建人工心肺辅助装置在体性能可靠。
목적：초보고찰편휴식인공심폐보조장치적재체성능。방법응용간소도층중공섬유양합기술여자현부리심빙장치정합구건소형화、편휴식심폐보조장치。40 kg실험양（ n＝6）재전마하제오륵간좌전외측절구，분별치입우심방삽관련접지인공심폐보조장치류입도，강주동맥삽관련접지장치류출도개시전류，4．0 L／min운전12 h，우전류전화전류후매2 h검측장치류입도급류출도혈양포화도，양분압，이양화탄분압등，계산장치양합효솔。취정맥혈검측유리혈홍단백검함량평개장치용혈성능병검측혈소판격활솔。결과12 h중，장치류출도양포화도보지98％이상，양합효솔은정。4．0 L／min류량운행12 h，유리혈홍단백함량균재20 g／L이하，혈소판격활균소우8％。결론응용간소도층중공섬유양합기여자현부리심혈빙구건인공심폐보조장치재체성능가고。
Objective To evaluate the performance of a wearable artificial cardiopulmonary support device in vivo . Methods Heparin-coating hollow fiber and axial pump were used to setup a wearable artificial cardiopulmonary support device. Six 40-kg sheepwere used in the study. The left anterolateral thoracotomy were performed after general anesthesia. Then the veno-arterial connectionswere setup with cannulation in the right atrium and descending aorta. The saturation, partial oxygen pressure and partial carbon dioxidepressure of the inlet and outlet were measured, and oxygen transfer rate was calculated before operating devices and then every 2 hoursat 4.0L/ min for 12 hours. The plasma free hemoglobin and platelet activation were evaluated every 2 hours as well. Results The satu?ration of outlet was stable at over 98% during the study. The plasma free hemoglobin was lower than 20mg/ dL and the platelet activationwas lower than 8% over 12 hours. Conclusions The wearable artificial cardiopulmonary support device with heparin-coating hollow fi?ber and axial pump conducted the reliable performance in vivo.