CAJ | 학술논문

目的探讨信号传导及转录活化因子3(STAT3)和脑胶质瘤相关癌基因1(Gli1)在大肠癌组织中的表达水平及临床意义.方法原发性大肠癌患者69例,采用免疫组织化学法检测STAT3和Gli1在大肠癌组织及相应癌旁组织中的表达水平,分析STAT3和Gli1的表达水平与大肠癌临床病理学之间的关系.结果 STAT3在大肠癌组织中表达率明显高于癌旁组织(60.87％比11.59％,P＜0.01),Gli1在大肠癌组织中表达率明显高于癌旁组织(75.36％比37.68％,P＜0.01);STAT3表达水平与大肠癌组织学分级、浸润深度、TNM分期和淋巴结转移明显相关(P＜0.05),Gli1表达水平与大肠癌组织学分级、TNM分期、淋巴结转移明显相关(P＜0.05).结论联合检测STAT3和Gli1有助于评价大肠癌的恶性程度,判断其转移潜能.
목적 탐토신호전도급전록활화인자3(STAT3)화뇌효질류상관암기인1(Gli1)재대장암조직중적표체수평급림상의의.방법 원발성대장암환자69례,채용면역조직화학법검측STAT3화Gli1재대장암조직급상응암방조직중적표체수평,분석STAT3화Gli1적표체수평여대장암림상병이학지간적관계.결과 STAT3재대장암조직중표체솔명현고우암방조직(60.87％비11.59％,P＜0.01),Gli1재대장암조직중표체솔명현고우암방조직(75.36％비37.68％,P＜0.01);STAT3표체수평여대장암조직학분급、침윤심도、TNM분기화림파결전이명현상관(P＜0.05),Gli1표체수평여대장암조직학분급、TNM분기、림파결전이명현상관(P＜0.05).결론 연합검측STAT3화Gli1유조우평개대장암적악성정도,판단기전이잠능.
Objective To explore the expression of signal transducer and activator of transcription 3 (STAT3),and glioma-associated oncogene 1 (Gli1) and the clinical significance in colorectal carcinoma.Methods Ninety-nine cases of colorectal carcinoma tissues and non-cancerous adjacent colorectal tissues were obtained for detection of the expression of STAT3 and Gli1 by immunohistochemistry.The relationship between the expression of STAT3 and Gli1 in colorectal carcinoma tissues and clinicopathologic features were analyzed.Results The expression rate of STAT3 and Gli1 in colorectal carcinoma tissues was higher than that in non-cancerous adjacent colorectal tissues (60.87％ vs.11.59％,and 75.36％ vs.37.68％,P ＜0.01).The expression of STAT3 was related to histology grade,serosa invasion,TNM stage and lymph node metastasis of colorectal carcinoma (P ＜ 0.05).There was a close relationship in colorectal carcinoma between the expression of Gli1 and histology grade,TNM stage and lymph node metastasis (P ＜ 0.05).Conclusion Simultaneous detection of STAT3 and Gli1 might be helpful for evaluating the malignance and predicting the metastatic potential of colorectal carcinoma.