中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2015年
6期
1413-1414
,共2页
Jagged1%CD147%大肠癌
Jagged1%CD147%大腸癌
Jagged1%CD147%대장암
Jagged1%CD147%Colorectal carcinoma
目的 探讨Jagged1和CD147在大肠癌组织中Jagged1和CD147的表达水平及临床价值.方法 收集82例大肠癌患者手术切除的肿瘤组织及相应癌旁组织,采用免疫组织化学法检测组织中Jagged1和CD147的表达水平.结果 Jagged1在大肠癌组织中表达率明显高于癌旁组织(78.82％比16.47％,P＜0.01),Jagged1表达水平与大肠癌浸润深度、TNM分期和淋巴结转移明显相关(P＜0.05);CD147在大肠癌组织中表达率明显高于癌旁组织(55.29％比21.18％,P＜0.01),CD147表达水平与大肠癌组织学分级、TNM分期、淋巴结转移明显相关(P＜0.05).结论 Jagged1和CD147在大肠癌的发生发展过程中发挥重要作用.
目的 探討Jagged1和CD147在大腸癌組織中Jagged1和CD147的錶達水平及臨床價值.方法 收集82例大腸癌患者手術切除的腫瘤組織及相應癌徬組織,採用免疫組織化學法檢測組織中Jagged1和CD147的錶達水平.結果 Jagged1在大腸癌組織中錶達率明顯高于癌徬組織(78.82％比16.47％,P＜0.01),Jagged1錶達水平與大腸癌浸潤深度、TNM分期和淋巴結轉移明顯相關(P＜0.05);CD147在大腸癌組織中錶達率明顯高于癌徬組織(55.29％比21.18％,P＜0.01),CD147錶達水平與大腸癌組織學分級、TNM分期、淋巴結轉移明顯相關(P＜0.05).結論 Jagged1和CD147在大腸癌的髮生髮展過程中髮揮重要作用.
목적 탐토Jagged1화CD147재대장암조직중Jagged1화CD147적표체수평급림상개치.방법 수집82례대장암환자수술절제적종류조직급상응암방조직,채용면역조직화학법검측조직중Jagged1화CD147적표체수평.결과 Jagged1재대장암조직중표체솔명현고우암방조직(78.82％비16.47％,P＜0.01),Jagged1표체수평여대장암침윤심도、TNM분기화림파결전이명현상관(P＜0.05);CD147재대장암조직중표체솔명현고우암방조직(55.29％비21.18％,P＜0.01),CD147표체수평여대장암조직학분급、TNM분기、림파결전이명현상관(P＜0.05).결론 Jagged1화CD147재대장암적발생발전과정중발휘중요작용.
Objective To investigate the expression of Jagged1 and CD147 in colorectal carcinoma and its clinical value.Methods Immunohistochemistry was used to detect the expression of Jagged1 and CD147 in 85 cases of colorectal carcinoma tissues and non-cancerous adjacent colorectal tissues.Results The expression rate of Jagged1 in colorectal carcinoma tissues was higher than that in non-cancerous adjacent colorectal tissues (78.82％ vs.16.47％,P ＜0.01).The expression of Jagged1 was related to serosa invasion,TNM stage and lymph node metastasis of colorectal carcinoma (P ＜ 0.05).The expression rate of CD147 in colorectal carcinoma tissues was higher than that in non-cancerous adjacent colorectal tissues (55.29％ vs.21.18％,P ＜ 0.01),and there was a close correlation between the expression of CD147 and histologic grade,TNM stage and lymph node metastasis of colorectal carcinoma (P ＜ 0.05).Conclusion Jagged1 and CD147 might be play an important role in the carcinogenesis of colorectal carcinoma,and might be the markers for evaluating prognosis of colorectal carcinoma.
