心血管康复医学杂志
心血管康複醫學雜誌
심혈관강복의학잡지
JOURNAL OF CARDIOVASCULAR REHABILITATION MEDICINE
2015年
3期
277-279
,共3页
心肌梗死%缺血后处理%心肌再灌注
心肌梗死%缺血後處理%心肌再灌註
심기경사%결혈후처리%심기재관주
Myocardial infarction%Ischemic postconditioning%Myocardial reperfusion
目的:探讨ST段抬高型心肌梗死(STEMI)急诊介入治疗中缺血后处理对心肌的保护作用。方法:选择广西医科大学附属医院2011年1月~2012年12月心内科住院,且在12h内行冠状动脉介入治疗(PCI )的82例STEMI患者,根据处理方法不同分为缺血后处理组(42例)和单纯再灌注组(40例),评价两组心功能情况等。结果:与单纯再灌注组比较,缺血后处理组ST段完全回落率(55.0%比81.0%)、左室射血分数[(0.5±0.1)比(0.7±0.1)]明显提高,心律失常率(60.0%比21.4%),室壁运动计分[WMSI ,(2.0±0.7)分比(1.3±0.6)分]、心肌梗死面积[MIS ,(15.1±7.1)%比(9.9±5.3)%]、核素心肌灌注缺损范围分数[ES ,(0.4±0.1)%比(0.2±0.1)%]和核素心肌灌注缺损严重程度积分[SS ,(2.3±1.1)%比(1.8±1.2)%]均显著减少(P<0.05~<0.01)。结论:缺血后处理可显著改善ST段抬高型心肌梗死患者心肌缺血再灌注损伤程度,保护心肌组织。
目的:探討ST段抬高型心肌梗死(STEMI)急診介入治療中缺血後處理對心肌的保護作用。方法:選擇廣西醫科大學附屬醫院2011年1月~2012年12月心內科住院,且在12h內行冠狀動脈介入治療(PCI )的82例STEMI患者,根據處理方法不同分為缺血後處理組(42例)和單純再灌註組(40例),評價兩組心功能情況等。結果:與單純再灌註組比較,缺血後處理組ST段完全迴落率(55.0%比81.0%)、左室射血分數[(0.5±0.1)比(0.7±0.1)]明顯提高,心律失常率(60.0%比21.4%),室壁運動計分[WMSI ,(2.0±0.7)分比(1.3±0.6)分]、心肌梗死麵積[MIS ,(15.1±7.1)%比(9.9±5.3)%]、覈素心肌灌註缺損範圍分數[ES ,(0.4±0.1)%比(0.2±0.1)%]和覈素心肌灌註缺損嚴重程度積分[SS ,(2.3±1.1)%比(1.8±1.2)%]均顯著減少(P<0.05~<0.01)。結論:缺血後處理可顯著改善ST段抬高型心肌梗死患者心肌缺血再灌註損傷程度,保護心肌組織。
목적:탐토ST단태고형심기경사(STEMI)급진개입치료중결혈후처리대심기적보호작용。방법:선택엄서의과대학부속의원2011년1월~2012년12월심내과주원,차재12h내행관상동맥개입치료(PCI )적82례STEMI환자,근거처리방법불동분위결혈후처리조(42례)화단순재관주조(40례),평개량조심공능정황등。결과:여단순재관주조비교,결혈후처리조ST단완전회락솔(55.0%비81.0%)、좌실사혈분수[(0.5±0.1)비(0.7±0.1)]명현제고,심률실상솔(60.0%비21.4%),실벽운동계분[WMSI ,(2.0±0.7)분비(1.3±0.6)분]、심기경사면적[MIS ,(15.1±7.1)%비(9.9±5.3)%]、핵소심기관주결손범위분수[ES ,(0.4±0.1)%비(0.2±0.1)%]화핵소심기관주결손엄중정도적분[SS ,(2.3±1.1)%비(1.8±1.2)%]균현저감소(P<0.05~<0.01)。결론:결혈후처리가현저개선ST단태고형심기경사환자심기결혈재관주손상정도,보호심기조직。
Objective:To explore the protective effect of ischemic postconditioning on myocardium during emergency percutaneous coronary intervention (PCI) in patients with ST segment elevation myocardial infarction (STEMI) . Methods:According to different treatment method ,a total of 82 STEMI patients ,who hospitalized in the depart-ment of Cardiology of Affiliated Hospital of Guangxi Medical University from Jan 2011 to Dec 2012 and received PCI within 12h ,were divided into ischemic postconditioning group (n= 42) and pure reperfusion group (n= 40) . Heart function etc .were evaluated in both groups .Results:Compared with pure reperfusion group ,there were sig-nificant rise in complete ST segment resolution rate (55.0% vs .81.0% ) and left ventricular ejection fraction [ (0.5 ± 0.1) vs .(0.7 ± 0.1)] ,significant reductions in arrhythmia rate (60.0% vs .21.4% ) ,wall motion score index [WMSI ,(2.0 ± 0.7) scores vs .(1.3 ± 0.6) scores] ,myocardial infarction size [MIS ,(15.1 ± 7.1)% vs .(9.9 ± 5.3)% ] ,radionuclide myocardial perfusion defect extent score [ES ,(0.4 ± 0.1)% vs .(0.2 ± 0.1)% ] and severity score [SS ,(2.3 ± 1.1)% vs .(1.8 ± 1.2)% ] in ischemic postconditioning group ,P<0.05~ <0.01 .Conclusion:Is-chemic postconditioning can significantly improve extent of myocardial ischemia reperfusion injury and protect myo-cardial tissues in STEMI patients .