实用皮肤病学杂志
實用皮膚病學雜誌
실용피부병학잡지
JOURNAL OF PRACTRCAL DERMATOLOGY
2015年
3期
178-180
,共3页
白癜风,面部%308 nm准分子光%窄谱中波紫外线
白癜風,麵部%308 nm準分子光%窄譜中波紫外線
백전풍,면부%308 nm준분자광%착보중파자외선
Vitiligo,face%308 nm excimer light%Ultraviolet B,narrowband
目的：比较308 nm单频准分子光（308 nm monochromatic excimer light, MEL)与窄谱中波紫外线（narrowband ultraviolet B, NB-UVB）治疗面部白癜风的临床疗效。方法选择面部白癜风患者相邻或对称分布的两处白斑分别照射308 nm MEL或NB-UVB，每周2次，共照射20次。结果308 nm MEL组复色达2级需要的平均照射次数为（8.6±1.31）次，NB-UVB组为（15.8±4.29）次，308 nm MEL组明显少于NB-UVB组，差异有统计学意义（P＜0.05）。308 nm MEL组的总有效率为92.13%，显效率为42.70%，NB-UVB组的总有效率为86.52%，显效率为31.46%。308 nm MEL组的显效率明显高于NB-UVB组，差异有统计学意义（P＜0.05）。两组的总有效率无统计学意义（P＞0.05）。两组的主要不良反应均为暂时性红斑和局部水疱，患者均能耐受。结论308 nm EML治疗面部白癜风比NB-UVB疗效更好，复色更快，但不良反应相似。
目的：比較308 nm單頻準分子光（308 nm monochromatic excimer light, MEL)與窄譜中波紫外線（narrowband ultraviolet B, NB-UVB）治療麵部白癜風的臨床療效。方法選擇麵部白癜風患者相鄰或對稱分佈的兩處白斑分彆照射308 nm MEL或NB-UVB，每週2次，共照射20次。結果308 nm MEL組複色達2級需要的平均照射次數為（8.6±1.31）次，NB-UVB組為（15.8±4.29）次，308 nm MEL組明顯少于NB-UVB組，差異有統計學意義（P＜0.05）。308 nm MEL組的總有效率為92.13%，顯效率為42.70%，NB-UVB組的總有效率為86.52%，顯效率為31.46%。308 nm MEL組的顯效率明顯高于NB-UVB組，差異有統計學意義（P＜0.05）。兩組的總有效率無統計學意義（P＞0.05）。兩組的主要不良反應均為暫時性紅斑和跼部水皰，患者均能耐受。結論308 nm EML治療麵部白癜風比NB-UVB療效更好，複色更快，但不良反應相似。
목적：비교308 nm단빈준분자광（308 nm monochromatic excimer light, MEL)여착보중파자외선（narrowband ultraviolet B, NB-UVB）치료면부백전풍적림상료효。방법선택면부백전풍환자상린혹대칭분포적량처백반분별조사308 nm MEL혹NB-UVB，매주2차，공조사20차。결과308 nm MEL조복색체2급수요적평균조사차수위（8.6±1.31）차，NB-UVB조위（15.8±4.29）차，308 nm MEL조명현소우NB-UVB조，차이유통계학의의（P＜0.05）。308 nm MEL조적총유효솔위92.13%，현효솔위42.70%，NB-UVB조적총유효솔위86.52%，현효솔위31.46%。308 nm MEL조적현효솔명현고우NB-UVB조，차이유통계학의의（P＜0.05）。량조적총유효솔무통계학의의（P＞0.05）。량조적주요불량반응균위잠시성홍반화국부수포，환자균능내수。결론308 nm EML치료면부백전풍비NB-UVB료효경호，복색경쾌，단불량반응상사。
Objective To compare the efifcacy of 308nm monochromatic excimer light (MEL) and narrowband ultraviolet B (NB-UVB) phototherapy in the treatment of facial vitiligo. Methods One lesion in facial vitiligo patient was treated with the 308nm MEL and its jacent or symmetrical lesion was treated with the NB-UVB. Lesions were treated two times a week for a total of 20 sessions. Results 308 nm MEL group obtained score 2 repigmentation required a mean of (8.6±1.31) treatments, while NB-UVB group required more treatments (15.8±4.29) to achieve the same result (P<0.05). The total effective rate of 308 nm MEL group and NB-UVB group was 92.13%and 86.52%respectively, with no signiifcant difference (P>0.05). Of these lesions, 42.70%treated with 308 nm MEL and 31.46%treated with NB-UVB achieved an excellent repigmentation, there was signiifcant difference between the two group ( P<0.05). The adverse reaction was transient erythema and blister, and all patients of the two groups were well tolerant. Conclusion 308 nm MEL is more effective than NB-UVB in treating facial vitiligo and it induces repigmentation more rapidly, the adverse reaction is similar.
