心血管康复医学杂志
心血管康複醫學雜誌
심혈관강복의학잡지
JOURNAL OF CARDIOVASCULAR REHABILITATION MEDICINE
2015年
3期
255-258
,共4页
心力衰竭%血压监测 ,便携式%血栓形成
心力衰竭%血壓鑑測 ,便攜式%血栓形成
심력쇠갈%혈압감측 ,편휴식%혈전형성
Heart failure%Blood pressure monitoring,ambulatory%Thrombosis
目的:探讨慢性心力衰竭(CHF)患者血压与血栓前状态(PTS)的相关性。方法:从2010年4月至2013年2月入住我科的患者中选择心功能为NYHAⅡ级的96例纳入CHF组,再选择90例心功能正常的患者纳入正常对照组,检测两组白天、夜晚以及24h的血压,及 PTS相关指标,并对二者进行相关性分析。结果:与正常对照组比较,CHF组夜间舒张压[nDBP ,(80.53±7.73)mmHg比(84.74±8.74) mmHg],白昼收缩压标准差[dSSD ,(11.87±4.98) mmHg比(14.97±5.12) mmHg]、夜间收缩压标准差[nSSD ,(11.62±4.83) mmHg比(15.05±5.42) mm-Hg]和24h收缩压标准差[24hSSD ,(12.98±3.22) mmHg比(15.75±5.08) mmHg]明显升高(P<0.01);血浆血管性假血友病因子[vWF ,(75.64±6.83) IU/dl比(90.75±7.32) IU/dl]、D-二聚体[(0.31±0.03) g/L比(0.73±0.13) g/L]和纤溶酶原激活物抑制物-1[PAI-1,(22.33±1.14)μg/L比(27.46±1.15)μg/L]水平显著升高(P均<0.01)。CHF患者中,24hSSD与vWF和血小板α颗粒膜蛋白-140(GMP-140)呈显著正相关(r=0.403,0.452,P均<0.05),24h舒张压标准差(24hDSD)、夜间舒张压标准差(nDSD)与GMP-140呈显著正相关(r=0.421,0.413,P均<0.05),其他时段血压变异性与PTS指标均无显著相关性(P均>0.05)。结论:慢性心衰患者血压变异性显著升高,血栓前状态指标水平显著上升,二者呈显著正相关。
目的:探討慢性心力衰竭(CHF)患者血壓與血栓前狀態(PTS)的相關性。方法:從2010年4月至2013年2月入住我科的患者中選擇心功能為NYHAⅡ級的96例納入CHF組,再選擇90例心功能正常的患者納入正常對照組,檢測兩組白天、夜晚以及24h的血壓,及 PTS相關指標,併對二者進行相關性分析。結果:與正常對照組比較,CHF組夜間舒張壓[nDBP ,(80.53±7.73)mmHg比(84.74±8.74) mmHg],白晝收縮壓標準差[dSSD ,(11.87±4.98) mmHg比(14.97±5.12) mmHg]、夜間收縮壓標準差[nSSD ,(11.62±4.83) mmHg比(15.05±5.42) mm-Hg]和24h收縮壓標準差[24hSSD ,(12.98±3.22) mmHg比(15.75±5.08) mmHg]明顯升高(P<0.01);血漿血管性假血友病因子[vWF ,(75.64±6.83) IU/dl比(90.75±7.32) IU/dl]、D-二聚體[(0.31±0.03) g/L比(0.73±0.13) g/L]和纖溶酶原激活物抑製物-1[PAI-1,(22.33±1.14)μg/L比(27.46±1.15)μg/L]水平顯著升高(P均<0.01)。CHF患者中,24hSSD與vWF和血小闆α顆粒膜蛋白-140(GMP-140)呈顯著正相關(r=0.403,0.452,P均<0.05),24h舒張壓標準差(24hDSD)、夜間舒張壓標準差(nDSD)與GMP-140呈顯著正相關(r=0.421,0.413,P均<0.05),其他時段血壓變異性與PTS指標均無顯著相關性(P均>0.05)。結論:慢性心衰患者血壓變異性顯著升高,血栓前狀態指標水平顯著上升,二者呈顯著正相關。
목적:탐토만성심력쇠갈(CHF)환자혈압여혈전전상태(PTS)적상관성。방법:종2010년4월지2013년2월입주아과적환자중선택심공능위NYHAⅡ급적96례납입CHF조,재선택90례심공능정상적환자납입정상대조조,검측량조백천、야만이급24h적혈압,급 PTS상관지표,병대이자진행상관성분석。결과:여정상대조조비교,CHF조야간서장압[nDBP ,(80.53±7.73)mmHg비(84.74±8.74) mmHg],백주수축압표준차[dSSD ,(11.87±4.98) mmHg비(14.97±5.12) mmHg]、야간수축압표준차[nSSD ,(11.62±4.83) mmHg비(15.05±5.42) mm-Hg]화24h수축압표준차[24hSSD ,(12.98±3.22) mmHg비(15.75±5.08) mmHg]명현승고(P<0.01);혈장혈관성가혈우병인자[vWF ,(75.64±6.83) IU/dl비(90.75±7.32) IU/dl]、D-이취체[(0.31±0.03) g/L비(0.73±0.13) g/L]화섬용매원격활물억제물-1[PAI-1,(22.33±1.14)μg/L비(27.46±1.15)μg/L]수평현저승고(P균<0.01)。CHF환자중,24hSSD여vWF화혈소판α과립막단백-140(GMP-140)정현저정상관(r=0.403,0.452,P균<0.05),24h서장압표준차(24hDSD)、야간서장압표준차(nDSD)여GMP-140정현저정상관(r=0.421,0.413,P균<0.05),기타시단혈압변이성여PTS지표균무현저상관성(P균>0.05)。결론:만성심쇠환자혈압변이성현저승고,혈전전상태지표수평현저상승,이자정현저정상관。
Objective:To explore the correlation between blood pressure and prethrombotic state indexes in patients with chronic heart failure (CHF) .Methods:A total of 96 cases with NYHA classⅡselected from inpatients of our department from Apr 2010 to Feb 2013 were enrolled into CHF group ,another 90 patients with normal cardiac function were regarded as normal control group .Daytime ,nighttime and 24h blood pressure and related indexes of prethrombotic state were detec-ted in both groups .Correlation between blood pressure variability and prethrombotic state indexes were analyzed .Results:Compared with normal control group ,there were significant rise in nighttime diastolic blood pressure [nDBP ,(80.53 ± 7.73) mmHg vs .(84.74 ± 8.74) mmHg] ,daytime systolic blood pressure standard deviation [dSSD ,(11.87 ± 4.98) mm-Hg vs .(14.97 ± 5.12) mmHg] ,night time SSD [nSSD (11.62 ± 4.83) mmHg vs .(15.05 ± 5.42) mmHg] and 24hSSD [24hSSD ,(12.98 ± 3.22) mmHg vs .(15.75 ± 5.08) mmHg] , P<0.01;and significant increase in plasma levels of von Willebrand factor [vWF ,(75.64 ± 6.83) IU/dl vs .(90.75 ± 7.32) IU/dl] ,D-dimer [ (0.31 ± 0.03) g/L vs .(0.73 ± 0.13) g/L] and plasminogen activator inhibitor-1 [PAI-1 ,(22.33 ± 1.14) μg/L vs .(27.46 ± 1.15) μg/L] in CHF group ,P<0.01 all .In CHF patients ,24hSSD were positively correlated with vWF and granule membrane protein (GMP-140) levels (r=0.403 ,0.452 ,P<0.05 both) ,24hDSD and nDSD were positively correlated with GMP-140 level (r=0.421 ,0.413 ,P<0.05 both) ,there were no significant correlation among other blood pressure variability indexes and PTS indexes , P>0. 05 all .Conclusion:In CHF patients ,blood pressure variability and prethrombotic state indexes levels significantly rise ,the both are significant positive correlation .