中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2015年
6期
1233-1235
,共3页
周洪益%周志毅%邵剑锋%胡强%王志荣%王强%单玉喜%徐卓群
週洪益%週誌毅%邵劍鋒%鬍彊%王誌榮%王彊%單玉喜%徐卓群
주홍익%주지의%소검봉%호강%왕지영%왕강%단옥희%서탁군
内皮特异性分子1%膀胱尿路上皮癌%临床病理
內皮特異性分子1%膀胱尿路上皮癌%臨床病理
내피특이성분자1%방광뇨로상피암%림상병리
Endothelial molecule-1%Bladder urothelial carcinoma%Clinicopathology immunohistochemistry
目的 探讨内皮特异性分子1(ESM-1)与膀胱尿路上皮癌临床及病理的关系.方法 收集95例膀胱尿路上皮癌临床及病理资料,取95例手术肿瘤组织样本及53例正常膀胱黏膜组织,采用免疫组织化学方法检测癌组织中ESM-1表达,正常膀胱黏膜组织作为对照研究.结果 膀胱尿路上皮癌中ESM-1阳性表达率为94.7％(90/95),而正常膀胱黏膜组织中的阳性表达率9.43％(5/53),差异有统计学意义(P＜0.01).ESM-1表达与肿瘤组织学分级:G1:78.6％ (11/14)、G2:96.8％ (61/63)、G3:100.0％ (18/18);肿瘤临床分期:Ta,T1:89.9％ (62/67)、T2 ～ T4:100.0％(28/28);淋巴结转移:无转移:71.4％ (5/7)、有转移:100.0％(6/6);术后复发:无复发:92.5％(62/67)、有复发:100.0％ (28/28)呈正相关(P＜0.01);ESM-1表达与膀胱尿路上皮癌患者性别、年龄、肿瘤大小及数目无明显相关;复发的癌组织ESM-1表达较初发癌组织强度显著增强:其初发强阳性表达率为50.0％(14/28)、复发强阳性表达率为75.0％(21/28,P＜0.01).结论 ESM-1在膀胱尿路上皮癌组织中表达显著增高,并与肿瘤组织学分级及临床分期密切相关.膀胱尿路上皮癌组织中ESM-1表达可能参与了膀胱癌的发生、生长、侵袭及转移.
目的 探討內皮特異性分子1(ESM-1)與膀胱尿路上皮癌臨床及病理的關繫.方法 收集95例膀胱尿路上皮癌臨床及病理資料,取95例手術腫瘤組織樣本及53例正常膀胱黏膜組織,採用免疫組織化學方法檢測癌組織中ESM-1錶達,正常膀胱黏膜組織作為對照研究.結果 膀胱尿路上皮癌中ESM-1暘性錶達率為94.7％(90/95),而正常膀胱黏膜組織中的暘性錶達率9.43％(5/53),差異有統計學意義(P＜0.01).ESM-1錶達與腫瘤組織學分級:G1:78.6％ (11/14)、G2:96.8％ (61/63)、G3:100.0％ (18/18);腫瘤臨床分期:Ta,T1:89.9％ (62/67)、T2 ～ T4:100.0％(28/28);淋巴結轉移:無轉移:71.4％ (5/7)、有轉移:100.0％(6/6);術後複髮:無複髮:92.5％(62/67)、有複髮:100.0％ (28/28)呈正相關(P＜0.01);ESM-1錶達與膀胱尿路上皮癌患者性彆、年齡、腫瘤大小及數目無明顯相關;複髮的癌組織ESM-1錶達較初髮癌組織彊度顯著增彊:其初髮彊暘性錶達率為50.0％(14/28)、複髮彊暘性錶達率為75.0％(21/28,P＜0.01).結論 ESM-1在膀胱尿路上皮癌組織中錶達顯著增高,併與腫瘤組織學分級及臨床分期密切相關.膀胱尿路上皮癌組織中ESM-1錶達可能參與瞭膀胱癌的髮生、生長、侵襲及轉移.
목적 탐토내피특이성분자1(ESM-1)여방광뇨로상피암림상급병리적관계.방법 수집95례방광뇨로상피암림상급병리자료,취95례수술종류조직양본급53례정상방광점막조직,채용면역조직화학방법검측암조직중ESM-1표체,정상방광점막조직작위대조연구.결과 방광뇨로상피암중ESM-1양성표체솔위94.7％(90/95),이정상방광점막조직중적양성표체솔9.43％(5/53),차이유통계학의의(P＜0.01).ESM-1표체여종류조직학분급:G1:78.6％ (11/14)、G2:96.8％ (61/63)、G3:100.0％ (18/18);종류림상분기:Ta,T1:89.9％ (62/67)、T2 ～ T4:100.0％(28/28);림파결전이:무전이:71.4％ (5/7)、유전이:100.0％(6/6);술후복발:무복발:92.5％(62/67)、유복발:100.0％ (28/28)정정상관(P＜0.01);ESM-1표체여방광뇨로상피암환자성별、년령、종류대소급수목무명현상관;복발적암조직ESM-1표체교초발암조직강도현저증강:기초발강양성표체솔위50.0％(14/28)、복발강양성표체솔위75.0％(21/28,P＜0.01).결론 ESM-1재방광뇨로상피암조직중표체현저증고,병여종류조직학분급급림상분기밀절상관.방광뇨로상피암조직중ESM-1표체가능삼여료방광암적발생、생장、침습급전이.
Objective The expression of human endothelial molecule-1 (ESM-1) and the relations between ESM-1 expression and clinicopathological parameters in bladder urothelial carcinoma (BUC) tissues and the role of ESM-1 in angiogenesis were investigated,to study the action of ESM-1 in carcinogenesis,invasion and metastasis of tumor.Methods and materials ESM-1 expression in 95 specimens of bladder urothelial carcinoma was measured by the method of immunohistochemistry.cytoplasmic and/or nucleus immunostaining in tumor cells were considered positive.Results (1) cytoplasmic and/or nucleus immunostaining was stained in tumor cells.In the BUC,there were 90 cases with expression of ESM-1 protein,the rate was 94.7％,while there were only 9.43％ in the adjacent normal tissues,there were significant difference between them (P ＜ 0.01).ESM-1 expression in cancer tissues was significantly higher than in adjacent normal tissues.(2) ESM-1 expression in BUC was positively correlated with histological grade (G1:78.6％ (11/14)/G2:96.8％ (61/63)/G3:100.0％ (18/18),clinical stage (Ta,T1:89.9％ (62/67)/T2-T4:100.0％ (28/28),lymph node metastasis (negative:71.4％ (5/7) / positive:100.0％ (6/6) and relapse (negative:92.5 ％ (62/67)/positive:100.0％ (28/28).There was not correlation between ESM-1 expression and age/gender or the number and size of tumor.ESM-1 expression of relapse of BUC was significantly higher than the initial issuance of BUC,and there were significant differences (high expression rate of primary:50.0％ (14/28)/relapse:75.0％ (21/28).Conclusion By immunohistochemistry,the study showed that ESM-1 may play a role as an oncogene during the tumorigenesis and development of BUC,its abnormal protein expression was closely related to clinical pathology,Therefore,abnormal expression of ESM-1 protein may suggest that the ESM-1 involved in the carcinogenesis,growth,invasion and metastasis of bladder urothelial cancer.
