中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2015年
11期
4-6
,共3页
慢性心力衰竭%心内科%比索洛尔%临床疗效
慢性心力衰竭%心內科%比索洛爾%臨床療效
만성심력쇠갈%심내과%비색락이%림상료효
Chronic heart failure%Cardiology%Bisoprolol%Clinical curative effect
目的 探讨比索洛尔治疗高血压慢性心力衰竭的临床疗效和安全性.方法 选取2013年2月至2014年2月文登中心医院收治的慢性心力衰竭患者60例,按照随机数字表法分为观察组和对照组,每组30例.对照组给予常规抗心力衰竭治疗,观察组在对照组的基础上加用比索洛尔治疗,疗程均为4周.观察指标包括:治疗前后NYHA心功能分级、Lee心力衰竭积分、中医证候评分、生活质量评分、6 min步行试验、超声心动图指标及血浆N-末端脑钠肽前体(NT-proBNP)、凋亡因子(Fas)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)等细胞因子水平.结果 治疗前各项观察指标比较差异未见统计学意义(P＞0.05);两组治疗后心功能分级、Lee心力衰竭积分、生活质量评分、6 min步行试验、超声心动图指标(E/A除外)及血浆NT-proBNP、Fas、TNF-α、IL-6等细胞因子水平均较治疗前明显改善,观察组改善情况明显优于对照组,差异有统计学意义(P＜0.05).结论 比索洛尔治疗高血压慢性心力衰竭临床疗效显著,值得临床推广应用.
目的 探討比索洛爾治療高血壓慢性心力衰竭的臨床療效和安全性.方法 選取2013年2月至2014年2月文登中心醫院收治的慢性心力衰竭患者60例,按照隨機數字錶法分為觀察組和對照組,每組30例.對照組給予常規抗心力衰竭治療,觀察組在對照組的基礎上加用比索洛爾治療,療程均為4週.觀察指標包括:治療前後NYHA心功能分級、Lee心力衰竭積分、中醫證候評分、生活質量評分、6 min步行試驗、超聲心動圖指標及血漿N-末耑腦鈉肽前體(NT-proBNP)、凋亡因子(Fas)、腫瘤壞死因子-α(TNF-α)、白細胞介素-6(IL-6)等細胞因子水平.結果 治療前各項觀察指標比較差異未見統計學意義(P＞0.05);兩組治療後心功能分級、Lee心力衰竭積分、生活質量評分、6 min步行試驗、超聲心動圖指標(E/A除外)及血漿NT-proBNP、Fas、TNF-α、IL-6等細胞因子水平均較治療前明顯改善,觀察組改善情況明顯優于對照組,差異有統計學意義(P＜0.05).結論 比索洛爾治療高血壓慢性心力衰竭臨床療效顯著,值得臨床推廣應用.
목적 탐토비색락이치료고혈압만성심력쇠갈적림상료효화안전성.방법 선취2013년2월지2014년2월문등중심의원수치적만성심력쇠갈환자60례,안조수궤수자표법분위관찰조화대조조,매조30례.대조조급여상규항심력쇠갈치료,관찰조재대조조적기출상가용비색락이치료,료정균위4주.관찰지표포괄:치료전후NYHA심공능분급、Lee심력쇠갈적분、중의증후평분、생활질량평분、6 min보행시험、초성심동도지표급혈장N-말단뇌납태전체(NT-proBNP)、조망인자(Fas)、종류배사인자-α(TNF-α)、백세포개소-6(IL-6)등세포인자수평.결과 치료전각항관찰지표비교차이미견통계학의의(P＞0.05);량조치료후심공능분급、Lee심력쇠갈적분、생활질량평분、6 min보행시험、초성심동도지표(E/A제외)급혈장NT-proBNP、Fas、TNF-α、IL-6등세포인자수평균교치료전명현개선,관찰조개선정황명현우우대조조,차이유통계학의의(P＜0.05).결론 비색락이치료고혈압만성심력쇠갈림상료효현저,치득림상추엄응용.
Objective To study the clinical effect of Bisoprolol on chronic heart failure.Methods Sixty cases of hypertension chronic heart failure in Wendeng central hospital from February 2013 to February 2013 were divided into observation group and control group (30 cases in each group),according to random number table method.The control group was given conventional medicine treatment,the observation group was given the bisoprolol on the basis of the control group,a course of 4 weeks.Observation indexes including:NYHA cardiac function classification,Lee heart failure points,TCM syndrome score,quality of life score,6 minutes walk test,echocardiographic indexes and plasma NT-proBNP,Fas,TNF-alpha,IL-6 levels before and after the treatment.Results Before the treatment,the observation indexes of the two group had no significant difference (P ＞ 0.05) ; The NYHA cardiac function classification,Lee heart failure points,TCM syndrome score,quality of life score,6 minutes walk test,echocardiographic indexes and plasma NT-proBNP,Fas,TNF-alpha,IL-6 levels of the two groups after treatment was obviously improved than that of before treatment,the observation group was obviously superior to control group,the differences were significant (P ＜ 0.05).Conclusions The clinical effect of bisoprolol on chronic heart failure is distinct,it is worthy of clinical application.
