中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2015年
11期
11-12
,共2页
中成药%通心络%兔腹主动脉%动脉球囊%损伤%血栓
中成藥%通心絡%兔腹主動脈%動脈毬囊%損傷%血栓
중성약%통심락%토복주동맥%동맥구낭%손상%혈전
Chinese medicine%Tongxinluo%Rabbit abdominal aorta%Artery balloon%Injury%Thrombosis
目的 探讨中成药通心络对兔腹主动脉及骼动脉球囊损伤后血栓的影响.方法 随机选取90只健康新西兰兔分为三组,模拟损伤后分别给予三组兔子通心络、阿司匹林和安慰剂治疗,取受损节段血管,经HE染色后放置在显微镜下对内膜增生及管腔内血栓形成情况进行观察.结果 三组兔子在球囊损伤后1、7d观察可发现髂动脉内膜增生及血管腹主动脉,管腔狭窄程度为5％～40％;模拟损伤后1个月,安慰剂组兔子腹主动脉髂及动脉内膜增生与阿司匹林组及痛心络组比较更加显著(P＜0.05);通心络膜增生的血管比例及血栓形成血管比例均明显少于其他两组(P＜0.05).结论 兔腹主动脉及骼动脉球囊损伤可作为理想的研究模型,在再狭窄防治中使用通心络治疗能够有效预防血栓发生,可进一步作为有效方案进行研究.
目的 探討中成藥通心絡對兔腹主動脈及骼動脈毬囊損傷後血栓的影響.方法 隨機選取90隻健康新西蘭兔分為三組,模擬損傷後分彆給予三組兔子通心絡、阿司匹林和安慰劑治療,取受損節段血管,經HE染色後放置在顯微鏡下對內膜增生及管腔內血栓形成情況進行觀察.結果 三組兔子在毬囊損傷後1、7d觀察可髮現髂動脈內膜增生及血管腹主動脈,管腔狹窄程度為5％～40％;模擬損傷後1箇月,安慰劑組兔子腹主動脈髂及動脈內膜增生與阿司匹林組及痛心絡組比較更加顯著(P＜0.05);通心絡膜增生的血管比例及血栓形成血管比例均明顯少于其他兩組(P＜0.05).結論 兔腹主動脈及骼動脈毬囊損傷可作為理想的研究模型,在再狹窄防治中使用通心絡治療能夠有效預防血栓髮生,可進一步作為有效方案進行研究.
목적 탐토중성약통심락대토복주동맥급격동맥구낭손상후혈전적영향.방법 수궤선취90지건강신서란토분위삼조,모의손상후분별급여삼조토자통심락、아사필림화안위제치료,취수손절단혈관,경HE염색후방치재현미경하대내막증생급관강내혈전형성정황진행관찰.결과 삼조토자재구낭손상후1、7d관찰가발현가동맥내막증생급혈관복주동맥,관강협착정도위5％～40％;모의손상후1개월,안위제조토자복주동맥가급동맥내막증생여아사필림조급통심락조비교경가현저(P＜0.05);통심락막증생적혈관비례급혈전형성혈관비례균명현소우기타량조(P＜0.05).결론 토복주동맥급격동맥구낭손상가작위이상적연구모형,재재협착방치중사용통심락치료능구유효예방혈전발생,가진일보작위유효방안진행연구.
Objective To investigate the effects of Chinese medicine Tongxinluo on thrombosis after abdominal aorta and iliac artery injury.Methods Randomly selected 90 healthy New Zealand rabbits,which were divided into three groups,the three groups of rabbits were given Tongxinluo,aspirin,placebo after simulated injuries,taking the damaged sections of blood vessels,after HE staining of endometrial placed under the microscope hyperplasia and thrombosis were observed within the lumen.Results The three groups of rabbits balloon injury 1,7 d after the observation can be found in the iliac artery and vascular aortic intimal hyperplasia,stenosis in 5％-40％ ; Simulate injuries a month later,the rabbit abdominal aorta and iliac artery intimal hyperplasia in placebo group was more significant than that in aspirin group and control group(P ＜0.05); Tongxinluo film proportion of angiogenesis and vascular thrombosis was significantly less than the proportion of the other two groups (P ＜ 0.05).Conclusions The abdominal aorta and iliac artery balloon injury can be used as an ideal research model in the prevention and treatment of restenosis.Tongxinluo can effectively prevent the occurrence of thrombosis,and can be further studied.
