CAJ | 학술논문

目的探讨不同高密度脂蛋白胆固醇(HDL-C)水平控制方案治疗冠心病(CAD)患者临床效果、安全性及预后影响.方法选取121例CAD患者为研究对象,随机分成非药物组(A组,n=61)和综合组(B组,n=60)两组.对比治疗前后HDL-C水平变化情况,记录其治疗后不良反应发生率,对比其生活质量.结果 ①两组患者治疗后HDL-C水平均较治疗前明显提升,其中B组提升幅度大于A组(P＜0.05);②A组治疗后不良反应率为8.2％,B组为16.7％,两组比较差异未见统计学意义(P＞0.05);③B组治疗后心绞痛改善程度明显高于A组(P＜0.01).结论对冠心病患者采用运动干预、饮食调控、戒烟禁酒联合烟酸及他汀类降脂药物方案,疗效突出,毒副反应轻微,预后质量较高,值得临床推广.
목적 탐토불동고밀도지단백담고순(HDL-C)수평공제방안치료관심병(CAD)환자림상효과、안전성급예후영향.방법 선취121례CAD환자위연구대상,수궤분성비약물조(A조,n=61)화종합조(B조,n=60)량조.대비치료전후HDL-C수평변화정황,기록기치료후불량반응발생솔,대비기생활질량.결과 ①량조환자치료후HDL-C수평균교치료전명현제승,기중B조제승폭도대우A조(P＜0.05);②A조치료후불량반응솔위8.2％,B조위16.7％,량조비교차이미견통계학의의(P＞0.05);③B조치료후심교통개선정도명현고우A조(P＜0.01).결론 대관심병환자채용운동간예、음식조공、계연금주연합연산급타정류강지약물방안,료효돌출,독부반응경미,예후질량교고,치득림상추엄.
Objective To investigate the clinical effect,safety and prognosis of different HDL-C level control scheme in the treatment of patients with CAD.Methods The 121 cases of CAD patients were chose as the research objects,and were randomly divided into non drug group (group A,n =61) and combined group (group B,n =60).HDL-C levels before and after treatment were compared,the incidence of adverse reaction and the quality of life was compared.Results The HDL-C levels improved significantly after treatment in both groups,the ascension of group B was greater than the group A (P ＜ 0.05); ②After treatment,the adverse reaction rate was 8.2％ in group A,and 16.7％ in group B,there was no significant difference (P ＞ 0.05) ; ③The degree of improvement in angina was higher in group B than that in group A (P ＜ 0.01).Conclusions In patients with cerebral vascular disease,exercise,diet control,smoking prohibition,with niacin and statin lipid-lowering drugs,has obvious curative effect and little adverse reaction,the prognosis has high quality,so is worthy the clinical promotion.