中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2015年
6期
654-655
,共2页
透明质酸%软骨,关节%细胞凋亡
透明質痠%軟骨,關節%細胞凋亡
투명질산%연골,관절%세포조망
Hyaluronic acid%Cartilage,articular%Apoptosis
目的 探讨早期关节腔内注射透明质酸对老年关节创伤后关节软骨细胞凋亡的影响.方法 选择2013年1月至2014年10月我院收治的89例老年关节创伤患者为研究对象,采用随机数字表法分为对照组40例,采用常规的手术和抗感染治疗;观察组49例,在常规治疗的基础上给予关节腔内注射透明质酸.比较分析两组软骨细胞凋亡率和细胞周期以及增殖指数. 结果 观察组细胞凋亡率(4.08±0.74)％比对照组(6.41±0.54)％低(t=16.403,P＜0.001);对照组G0/G1期细胞(91.7±4.3)％高于观察组(83.5±3.5)％(t=10.275,P＜0.001);对照组S(3.5±0.3)％和G2/M期细胞(4.7±0.6)％以及增殖指数(9.1±1.1)％低于观察组S(8.2±2.4)％和G2/M期细胞(8.5±1.8)％以及增殖指数(16.7±1.9)％(t=12.293、12.731和22.198,均P＜0.001). 结论 老年关节创伤后,早期关节腔内注射透明质酸可降低细胞凋亡率,有利于关节软骨细胞更替,促进患者康复.
目的 探討早期關節腔內註射透明質痠對老年關節創傷後關節軟骨細胞凋亡的影響.方法 選擇2013年1月至2014年10月我院收治的89例老年關節創傷患者為研究對象,採用隨機數字錶法分為對照組40例,採用常規的手術和抗感染治療;觀察組49例,在常規治療的基礎上給予關節腔內註射透明質痠.比較分析兩組軟骨細胞凋亡率和細胞週期以及增殖指數. 結果 觀察組細胞凋亡率(4.08±0.74)％比對照組(6.41±0.54)％低(t=16.403,P＜0.001);對照組G0/G1期細胞(91.7±4.3)％高于觀察組(83.5±3.5)％(t=10.275,P＜0.001);對照組S(3.5±0.3)％和G2/M期細胞(4.7±0.6)％以及增殖指數(9.1±1.1)％低于觀察組S(8.2±2.4)％和G2/M期細胞(8.5±1.8)％以及增殖指數(16.7±1.9)％(t=12.293、12.731和22.198,均P＜0.001). 結論 老年關節創傷後,早期關節腔內註射透明質痠可降低細胞凋亡率,有利于關節軟骨細胞更替,促進患者康複.
목적 탐토조기관절강내주사투명질산대노년관절창상후관절연골세포조망적영향.방법 선택2013년1월지2014년10월아원수치적89례노년관절창상환자위연구대상,채용수궤수자표법분위대조조40례,채용상규적수술화항감염치료;관찰조49례,재상규치료적기출상급여관절강내주사투명질산.비교분석량조연골세포조망솔화세포주기이급증식지수. 결과 관찰조세포조망솔(4.08±0.74)％비대조조(6.41±0.54)％저(t=16.403,P＜0.001);대조조G0/G1기세포(91.7±4.3)％고우관찰조(83.5±3.5)％(t=10.275,P＜0.001);대조조S(3.5±0.3)％화G2/M기세포(4.7±0.6)％이급증식지수(9.1±1.1)％저우관찰조S(8.2±2.4)％화G2/M기세포(8.5±1.8)％이급증식지수(16.7±1.9)％(t=12.293、12.731화22.198,균P＜0.001). 결론 노년관절창상후,조기관절강내주사투명질산가강저세포조망솔,유리우관절연골세포경체,촉진환자강복.
Objective To investigate the influence of intra-articular injection of hyaluronic acid at early stage on articular cartilage cells apoptosis in elderly patients with articular injury.Methods A total of 89 elderly patients with articular injury from Jan.2013 to Oct.2014 were randomly divided into observation group and control group.In control group,40 cases were treated with conventional surgery and anti-inflammatory therapy.In observation group,49 cases were treated intraarticular injection of hyaluronic acid added to conventional therapy.The apoptosis rate of articular cartilage cells,cell cycle and proliferation index were compared between the two groups.Results The apoptosis rate of articular cartilage cells was lower in observation group than in control group [(4.08±0.74)％ vs.(6.41±0.54)％,t=16.403,P＜0.001].The ratio of G0/Giin articular cartilage cells was lower in observation group than in control group[(83.5 ± 3.5)％ vs.(91.7± 4.3)％,t10.275,P＜0.001].The ratios of S and G2/M and the proliferation index in articular cartilage cells were lower in control group than in observation group[(3.5 ± 0.3)％ vs.(8.2± 2.4)％,(4.7±0.6)％ vs.(8.5±1.8)％ and (9.1±1.1)％ vs.(16.7±1.9)％,t=12.293,12.731 and 22.198,respectively,all P＜0.001].Conclusions Intra articular injection of hyaluronic acid at early stage decreases the apoptosis rate of articular cartilage cells,helps articular cartilage cells turnover and improves the recovery of articular injury in elderly patients.
