中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2015年
11期
53-54
,共2页
慢性心力衰竭%缬沙坦%卡维地洛%氨基末端脑钠尿肽原%左心功能
慢性心力衰竭%纈沙坦%卡維地洛%氨基末耑腦鈉尿肽原%左心功能
만성심력쇠갈%힐사탄%잡유지락%안기말단뇌납뇨태원%좌심공능
Chronic cardiac failure%Valsartan%Carvedilol%NT-proBNP%Left heart function
目的 探讨缬沙坦与卡维地洛联用对慢性充血性心力衰竭患者血清氨基末端脑钠尿肽原(NT-proBNP)水平及左心功能的影响.方法 将96例慢性心力衰竭住院患者随机分为观察组和对照组,每组48例,两组患者均给予常规抗心力衰竭治疗,观察组在此基础上加用缬沙坦与卡维地洛,治疗6个月后比较两组患者治疗前后血清NT-proBNP水平、左心功能变化及治疗过程中不良反应发生情况.结果 两组治疗前血清NT-proBNP水平比较差异未见统计学意义(P＞0.05),治疗后血清NT-proBNP水平均较治疗前明显降低,观察组血清NT-proBNP水平降低程度更为明显,组间比较差异有统计学意义(P＜0.05);两组治疗后左心室舒张末内径、左心室收缩末内径均较治疗前降低,左心室射血分数、心搏出量升高,观察组左心功能改善情况优于对照组,组间比较差异有统计学意义(P＜0.05).结论 缬沙坦联合卡维地洛治疗慢性心力衰竭可明显降低患者血清NT-proBNP水平,有效改善左心功能,无明显不良反应发生,临床应用安全、有效.
目的 探討纈沙坦與卡維地洛聯用對慢性充血性心力衰竭患者血清氨基末耑腦鈉尿肽原(NT-proBNP)水平及左心功能的影響.方法 將96例慢性心力衰竭住院患者隨機分為觀察組和對照組,每組48例,兩組患者均給予常規抗心力衰竭治療,觀察組在此基礎上加用纈沙坦與卡維地洛,治療6箇月後比較兩組患者治療前後血清NT-proBNP水平、左心功能變化及治療過程中不良反應髮生情況.結果 兩組治療前血清NT-proBNP水平比較差異未見統計學意義(P＞0.05),治療後血清NT-proBNP水平均較治療前明顯降低,觀察組血清NT-proBNP水平降低程度更為明顯,組間比較差異有統計學意義(P＜0.05);兩組治療後左心室舒張末內徑、左心室收縮末內徑均較治療前降低,左心室射血分數、心搏齣量升高,觀察組左心功能改善情況優于對照組,組間比較差異有統計學意義(P＜0.05).結論 纈沙坦聯閤卡維地洛治療慢性心力衰竭可明顯降低患者血清NT-proBNP水平,有效改善左心功能,無明顯不良反應髮生,臨床應用安全、有效.
목적 탐토힐사탄여잡유지락련용대만성충혈성심력쇠갈환자혈청안기말단뇌납뇨태원(NT-proBNP)수평급좌심공능적영향.방법 장96례만성심력쇠갈주원환자수궤분위관찰조화대조조,매조48례,량조환자균급여상규항심력쇠갈치료,관찰조재차기출상가용힐사탄여잡유지락,치료6개월후비교량조환자치료전후혈청NT-proBNP수평、좌심공능변화급치료과정중불량반응발생정황.결과 량조치료전혈청NT-proBNP수평비교차이미견통계학의의(P＞0.05),치료후혈청NT-proBNP수평균교치료전명현강저,관찰조혈청NT-proBNP수평강저정도경위명현,조간비교차이유통계학의의(P＜0.05);량조치료후좌심실서장말내경、좌심실수축말내경균교치료전강저,좌심실사혈분수、심박출량승고,관찰조좌심공능개선정황우우대조조,조간비교차이유통계학의의(P＜0.05).결론 힐사탄연합잡유지락치료만성심력쇠갈가명현강저환자혈청NT-proBNP수평,유효개선좌심공능,무명현불량반응발생,림상응용안전、유효.
Objective To investigate the effect of valsartan combined with carvedilol on serum NT-proBNP level and left heart function in the patients with chronic congestive heart-failure.Methods Ninety-six inpatients with chronic congestive heart-failure were ranolomly divided into observation group and control group,each group with 48 cases.Both groups were treated with routine heart failure treatment,the observation group was given carvedilol on the basis of routine heart failure treatment,the treatment course was 6 months.The serum NT-proBNP level,the change of left heart function and adverse reactions in the two groups before and after the treatment were compared.Results The serum NT-proBNP level between the two groups had no significant difference (P ＞ 0.05) before the treatment,well after the treatment,the serum NT-proBNP levels of the two groups decreased obviously and the serum NT-proBNP level of the patients in the observation group decreased more obviously,there was significant difference between the two groups (P ＜ 0.05).The LVEDD and LVSDD of the patients in the two groups decreased,the LVEF and SV increased in the two groups after the treatment.The improvement effect of left heart function in the observation group was better than that in control group,there was significant difference between the two groups(P ＜ 0.05).Conclusions Valsartan combined with carvedilol in treating chronic cardiac failure can decrease the serum NT-proBNP level of the patients obviously and improve their left heart function effectively,without obviously adverse reaction,so it is safe and effective.
