中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2015年
11期
61-62
,共2页
急性坏死性胰腺炎%乌司他丁%常规疗法%临床疗效
急性壞死性胰腺炎%烏司他丁%常規療法%臨床療效
급성배사성이선염%오사타정%상규요법%림상료효
Acute necrotizing pancreatitis%Ulinastatin%Conventional therapy%Clinical efficacy
目的 比较乌司他丁联合常规疗法与单用常规疗法治疗老年急性坏死性胰腺炎的临床疗效.方法 选择2011年6月至2014年6月胶州市人民医院收治的老年急性坏死性胰腺炎患者100例,随机分为观察组和对照组,每组50例.对照组给予常规方法治疗,治疗组给予乌司他丁联合常规疗法治疗.对两组患者治疗后的临床恢复指标、临床疗效及不良反应发生率进行比较.结果 治疗后观察组的血清淀粉酶(AMY)水平明显低于对照组,差异有统计学意义(P＜0.05).治疗后观察组的腹痛缓解时间、白细胞恢复正常时间、血淀粉酶恢复正常时间、尿淀粉酶恢复正常时间及平均住院时间均明显短于对照组,差异有统计学意义(P＜0.05).观察组总有效率(96.0％)明显高于对照组(82.0％),差异有统计学意义(P＜0.05).观察组不良反应发生率(10.0％)与对照组(8.0％)比较差异未见统计学意义(P＞0.05).结论 乌司他丁联合常规疗法在治疗老年急性坏死性胰腺炎中,可明显降低血清淀粉酶水平,提高临床恢复指标和临床疗效,具有一定临床应用价值.
目的 比較烏司他丁聯閤常規療法與單用常規療法治療老年急性壞死性胰腺炎的臨床療效.方法 選擇2011年6月至2014年6月膠州市人民醫院收治的老年急性壞死性胰腺炎患者100例,隨機分為觀察組和對照組,每組50例.對照組給予常規方法治療,治療組給予烏司他丁聯閤常規療法治療.對兩組患者治療後的臨床恢複指標、臨床療效及不良反應髮生率進行比較.結果 治療後觀察組的血清澱粉酶(AMY)水平明顯低于對照組,差異有統計學意義(P＜0.05).治療後觀察組的腹痛緩解時間、白細胞恢複正常時間、血澱粉酶恢複正常時間、尿澱粉酶恢複正常時間及平均住院時間均明顯短于對照組,差異有統計學意義(P＜0.05).觀察組總有效率(96.0％)明顯高于對照組(82.0％),差異有統計學意義(P＜0.05).觀察組不良反應髮生率(10.0％)與對照組(8.0％)比較差異未見統計學意義(P＞0.05).結論 烏司他丁聯閤常規療法在治療老年急性壞死性胰腺炎中,可明顯降低血清澱粉酶水平,提高臨床恢複指標和臨床療效,具有一定臨床應用價值.
목적 비교오사타정연합상규요법여단용상규요법치료노년급성배사성이선염적림상료효.방법 선택2011년6월지2014년6월효주시인민의원수치적노년급성배사성이선염환자100례,수궤분위관찰조화대조조,매조50례.대조조급여상규방법치료,치료조급여오사타정연합상규요법치료.대량조환자치료후적림상회복지표、림상료효급불량반응발생솔진행비교.결과 치료후관찰조적혈청정분매(AMY)수평명현저우대조조,차이유통계학의의(P＜0.05).치료후관찰조적복통완해시간、백세포회복정상시간、혈정분매회복정상시간、뇨정분매회복정상시간급평균주원시간균명현단우대조조,차이유통계학의의(P＜0.05).관찰조총유효솔(96.0％)명현고우대조조(82.0％),차이유통계학의의(P＜0.05).관찰조불량반응발생솔(10.0％)여대조조(8.0％)비교차이미견통계학의의(P＞0.05).결론 오사타정연합상규요법재치료노년급성배사성이선염중,가명현강저혈청정분매수평,제고림상회복지표화림상료효,구유일정림상응용개치.
Objective To compare the clinical efficacy of ulinastatin combined with conventional therapy and conventional therapy alone on elderly patients with acute necrotizing pancreatitis.Methods Totally 100 elderly patients with acute necrotizing pancreatitis from June 2011 to June 2014 were randomly divided into observation group and control group,with 50 cases in each group.Control group was treated by conventional therapy,while observation group was treated by ulinastatin combined with conventional therapy.Clinical recovery indicators,clinical efficacy and the incidence of adverse reactions of the patients between the two groups were compared.Results The level of AMY in observation group after treatment was significantly lower than that in control group,the difference was statistically significant (P ＜ 0.05).The abdominal pain relief time,white blood cells recovery time,blood amylase restoration time,urinary amylase restoration time and hospital stay in observation group after treatment were significantly shorter than those in control group,the differences were statistically significant (P ＜ 0.05).Total efficiency of observation group (96.0％) was significantly higher than that of control group (82.0％),the difference was statistically significant(P ＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05).Conclusions Ulinastatin combined with conventional therapy in the treatment of elderly patients with acute necrotizing pancreatitis can significantly reduce the level of AMY,enhance clinical recovery indicators and clinical efficacy.It has certain clinical applications.
