中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2015年
6期
1358-1360
,共3页
吴京%刘爱华%赵艺%符策基%彭汤明%钱增辉%康慧斌%吴中学
吳京%劉愛華%趙藝%符策基%彭湯明%錢增輝%康慧斌%吳中學
오경%류애화%조예%부책기%팽탕명%전증휘%강혜빈%오중학
血液黏滞性%颅内大型动脉瘤%剪切力%血流动力学
血液黏滯性%顱內大型動脈瘤%剪切力%血流動力學
혈액점체성%로내대형동맥류%전절력%혈류동역학
Blood viscosity%Large intracranial aneurysm%Wall shear stress%Hemodynamics
目的 应用血流动力学数值模拟技术分析不同血液黏滞系数对颅内大型动脉瘤剪切力水平的影响.方法 收集我院2013年6月至2013年7月收治的8例颅内大型囊性动脉瘤患者脑血管三维影像数据,其中破裂动脉瘤3例,未破裂动脉瘤5例.应用CFD ICEM软件对动脉瘤三维模型进行网格划分,再进行流体力学数值模拟计算.在血液黏滞系数为0.002、0.004和0.012 Pa·s 3种水平时对颅内大型动脉瘤进行血流动力学数值模拟运算并比较动脉瘤及载瘤动脉剪切力差异.结果 血液黏滞系数升高引起动脉瘤及载瘤动脉血流剪切力明显上升.血液黏滞系数为0.002、0.004和0.012 Pa·s时,相应的动脉瘤剪切力平均值分别为(2.79 ±2.23)、(5.27±3.72)和(11.05±7.56) Pa;载瘤动脉剪切力平均值为(5.61±2.59)、(9.56±3.74)和(22.56±12.41) Pa.在所有患者中,动脉瘤剪切力平均水平均低于载瘤动脉.结论 仅从剪切力对血管内皮细胞的影响作用角度分析,血液黏滞系数的异常上升或下降都可能加重剪切力对动脉瘤壁的损伤,增加颅内大型动脉瘤破裂风险.在进行颅内动脉瘤血流动力学相关研究时,有必要采用患者真实的血液黏滞系数,这样才能获得更加准确的实验结果.
目的 應用血流動力學數值模擬技術分析不同血液黏滯繫數對顱內大型動脈瘤剪切力水平的影響.方法 收集我院2013年6月至2013年7月收治的8例顱內大型囊性動脈瘤患者腦血管三維影像數據,其中破裂動脈瘤3例,未破裂動脈瘤5例.應用CFD ICEM軟件對動脈瘤三維模型進行網格劃分,再進行流體力學數值模擬計算.在血液黏滯繫數為0.002、0.004和0.012 Pa·s 3種水平時對顱內大型動脈瘤進行血流動力學數值模擬運算併比較動脈瘤及載瘤動脈剪切力差異.結果 血液黏滯繫數升高引起動脈瘤及載瘤動脈血流剪切力明顯上升.血液黏滯繫數為0.002、0.004和0.012 Pa·s時,相應的動脈瘤剪切力平均值分彆為(2.79 ±2.23)、(5.27±3.72)和(11.05±7.56) Pa;載瘤動脈剪切力平均值為(5.61±2.59)、(9.56±3.74)和(22.56±12.41) Pa.在所有患者中,動脈瘤剪切力平均水平均低于載瘤動脈.結論 僅從剪切力對血管內皮細胞的影響作用角度分析,血液黏滯繫數的異常上升或下降都可能加重剪切力對動脈瘤壁的損傷,增加顱內大型動脈瘤破裂風險.在進行顱內動脈瘤血流動力學相關研究時,有必要採用患者真實的血液黏滯繫數,這樣纔能穫得更加準確的實驗結果.
목적 응용혈류동역학수치모의기술분석불동혈액점체계수대로내대형동맥류전절력수평적영향.방법 수집아원2013년6월지2013년7월수치적8례로내대형낭성동맥류환자뇌혈관삼유영상수거,기중파렬동맥류3례,미파렬동맥류5례.응용CFD ICEM연건대동맥류삼유모형진행망격화분,재진행류체역학수치모의계산.재혈액점체계수위0.002、0.004화0.012 Pa·s 3충수평시대로내대형동맥류진행혈류동역학수치모의운산병비교동맥류급재류동맥전절력차이.결과 혈액점체계수승고인기동맥류급재류동맥혈류전절력명현상승.혈액점체계수위0.002、0.004화0.012 Pa·s시,상응적동맥류전절력평균치분별위(2.79 ±2.23)、(5.27±3.72)화(11.05±7.56) Pa;재류동맥전절력평균치위(5.61±2.59)、(9.56±3.74)화(22.56±12.41) Pa.재소유환자중,동맥류전절력평균수평균저우재류동맥.결론 부종전절력대혈관내피세포적영향작용각도분석,혈액점체계수적이상상승혹하강도가능가중전절력대동맥류벽적손상,증가로내대형동맥류파렬풍험.재진행로내동맥류혈류동역학상관연구시,유필요채용환자진실적혈액점체계수,저양재능획득경가준학적실험결과.
Objective To simulate the computational hemodynamics of large intracranial aneurysms and analyze the impact of blood viscosity on wall shear stress.Methods Eight large intracranial aneurysms at internal carotid artery between June 2013 and July 2013 were studied retrospectively.Among them,3 aneurysms were ruptured and 5 were unruptured.Pulsatile CFD simulations were carried out using three levels of blood viscosity (0.002,0.004,0.012 Pa·s).For each aneurysm model,the average wall shear stress (WSS) predicted by the three blood viscosity levels were compared.Results Blood viscosity has significant impaction on average wall shear stress of intracranial aneurysms and parent artery.Average wall shear stress increased significantly with the increase of blood viscosity.When blood viscosity was 0.002,0.004,0.012 Pa·s,the average wall shear stress of aneurysms was (2.79 ±2.23),(5.27 ±3.72) and (11.05 ± 7.56) Pa,respectively.The average wall shear stress of parent artery was (5.61 ± 2.59),(9.56 ± 3.74) and (22.56 ± 12.41) Pa respectively.A reduction in wall shear stress between the parent artery and the aneurysm sac was found in all the cases.Conclusion Abnormal increase or decrease in blood viscosity may aggravate vascular wall damage and increase the risk of aneurysmal rupture.It is necessary to adopt patient-specific value of blood viscosity in future hemodynamic studies of intracranial aneurysms.
