中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2015年
6期
601-604
,共4页
高血压%造血干细胞%钙通道阻滞药
高血壓%造血榦細胞%鈣通道阻滯藥
고혈압%조혈간세포%개통도조체약
Hypertension%Hematopoietic stem cells%Calcium channel blockers
目的 探讨乐卡地平治疗老年高血压患者的疗效和对外周血造血祖细胞数量的影响.方法 入选上海交通大学医学院附属仁济医院老年科2014年1-12月门诊就诊的高血压患者61例,数字抽签随机分为乐卡地平组32例,服用盐酸乐卡地平5～10 mg/d;对照组29例,降压药物根据患者情况采用噻嗪类利尿剂和(或)β受体阻滞剂,观察12周,目标血压为＜ 140/90 mmHg(1mmHg=0.133 kPa).用药前后检测患者血脂、血糖、肝肾功能及红细胞沉降率等实验室检查指标,采用流式细胞分析的方法检测外周造血祖细胞数量(以外周血CD34+ CD45dim细胞的数量外周血100 000个单核细胞的百分比进行计数). 结果 乐卡地平组用药后血压下降,患者血压均达标.血压下降幅度对照组与乐卡地平组比较差异无统计学意义(P＞0.05).乐卡地平治疗12周后CD34+ CD45dim细胞数升高(0.022±0.003)％与(0.034±0.028)％ (P＜0.05);与对照组比较,乐卡地平组CD34+ CD45dim细胞数量有上升趋势,但差异无统计学意义(P＞0.05).以CD34+ CD45dim数量为自变量,行多元逐步线性回归分析结果显示,收缩压与CD34+ CD45dim细胞数量呈负相关(B=-1.794,t=-23.04,P＜0.01). 结论 老年高血压患者外周血祖细胞数量与收缩压呈负相关.乐卡地平增加外周血祖细胞数量,且不依赖于其降压作用.
目的 探討樂卡地平治療老年高血壓患者的療效和對外週血造血祖細胞數量的影響.方法 入選上海交通大學醫學院附屬仁濟醫院老年科2014年1-12月門診就診的高血壓患者61例,數字抽籤隨機分為樂卡地平組32例,服用鹽痠樂卡地平5～10 mg/d;對照組29例,降壓藥物根據患者情況採用噻嗪類利尿劑和(或)β受體阻滯劑,觀察12週,目標血壓為＜ 140/90 mmHg(1mmHg=0.133 kPa).用藥前後檢測患者血脂、血糖、肝腎功能及紅細胞沉降率等實驗室檢查指標,採用流式細胞分析的方法檢測外週造血祖細胞數量(以外週血CD34+ CD45dim細胞的數量外週血100 000箇單覈細胞的百分比進行計數). 結果 樂卡地平組用藥後血壓下降,患者血壓均達標.血壓下降幅度對照組與樂卡地平組比較差異無統計學意義(P＞0.05).樂卡地平治療12週後CD34+ CD45dim細胞數升高(0.022±0.003)％與(0.034±0.028)％ (P＜0.05);與對照組比較,樂卡地平組CD34+ CD45dim細胞數量有上升趨勢,但差異無統計學意義(P＞0.05).以CD34+ CD45dim數量為自變量,行多元逐步線性迴歸分析結果顯示,收縮壓與CD34+ CD45dim細胞數量呈負相關(B=-1.794,t=-23.04,P＜0.01). 結論 老年高血壓患者外週血祖細胞數量與收縮壓呈負相關.樂卡地平增加外週血祖細胞數量,且不依賴于其降壓作用.
목적 탐토악잡지평치료노년고혈압환자적료효화대외주혈조혈조세포수량적영향.방법 입선상해교통대학의학원부속인제의원노년과2014년1-12월문진취진적고혈압환자61례,수자추첨수궤분위악잡지평조32례,복용염산악잡지평5～10 mg/d;대조조29례,강압약물근거환자정황채용새진류이뇨제화(혹)β수체조체제,관찰12주,목표혈압위＜ 140/90 mmHg(1mmHg=0.133 kPa).용약전후검측환자혈지、혈당、간신공능급홍세포침강솔등실험실검사지표,채용류식세포분석적방법검측외주조혈조세포수량(이외주혈CD34+ CD45dim세포적수량외주혈100 000개단핵세포적백분비진행계수). 결과 악잡지평조용약후혈압하강,환자혈압균체표.혈압하강폭도대조조여악잡지평조비교차이무통계학의의(P＞0.05).악잡지평치료12주후CD34+ CD45dim세포수승고(0.022±0.003)％여(0.034±0.028)％ (P＜0.05);여대조조비교,악잡지평조CD34+ CD45dim세포수량유상승추세,단차이무통계학의의(P＞0.05).이CD34+ CD45dim수량위자변량,행다원축보선성회귀분석결과현시,수축압여CD34+ CD45dim세포수량정부상관(B=-1.794,t=-23.04,P＜0.01). 결론 노년고혈압환자외주혈조세포수량여수축압정부상관.악잡지평증가외주혈조세포수량,차불의뢰우기강압작용.
Objective To investigate the effect of Lecarnidipine on hypertension and circulation hematopoietic progenitor cells (HPCs) count in elderly patients.Methods A total of 61 elderly patients with hypertension were selected in Renji Hospital geriatric hypertension clinic from January 2014 to August 2014.Patients were randomly divided into two groups:Lercanidipine treatment group (n=32,Lercanidipine hydrochloride 5-10 mg/day),the control group (n=29,thiazide diuretics and / or beta blockers according to patient's condition).Patients were observed for 12 weeks,and the target blood pressure level was ＜140/90 mmHg (1 mmHg=0.133 kPa).Blood lipids and glucose levels,liver and kidney function and erythrocyte sedimentation rate (ESR) were determined before and after treatment.The quantity of circulation HPCs (the percentage of CD34+ CD45dim in peripheral blood in 100000 mononuclear cells) was detected by flow cytometry analysis.Results Blood pressure in Lercanidipine treatment group was decreased after the treatment (P＜0.01),and patients reached the target blood pressure.There was no difference in the decrease of blood pressure level between the two groups (P＞0.05).The number of CD34+ CD45dim cells was increased after 12 weeks of Lecarnidipine treatment [(0.022 + 0.003)％ vs.(0.034 + 0.028)％,P＜0.05].Compared with the control group,the number of CD34+ CD45dim cells in lercanidipine group had a rising trend,but it had no statistical difference (P＞0.05).Taking the number of CD34+ CD45dim as the independent variables,the multiple stepwise linear regression analysis showed that the number of CD34+ CD45dim cells was negatively correlated to systolic pressure.Conclusions The number of circulation HPCs is negatively correlated with systolic pressure in the elderly.Lercanidipine can increase the number of circulation HPCs,and does not rely on its antihypertensive effect.
