CAJ | 학술논문

目的：探讨多功能高分子微泡（ MPMBs）双模式成像效能及其联合超声对DLBCL弥漫大B细胞淋巴瘤（ DLBCL）细胞株SU-DHL-4增殖和凋亡的影响。方法：以机械振荡法制备共载阿霉素及超顺磁性氧化铁的MPMBs，观察其体外增强B超、磁共振显影的能力；将SU-DHL-4细胞株按处理方法不同分组，CCK-8法检测各组细胞活力，吖啶橙／溴化乙啶（ AO／EB ）双染法观察细胞形态。结果：MPMBs较普通高分子微泡（ PMBs）具有更好的超声、磁共振显影效果；MPMBs联合超声对DLBCL细胞增殖的抑制强于其他处理组。结论：MPMBs是一种可集治疗与超声、磁共振成像于一体的多功能造影剂。
목적：탐토다공능고분자미포（ MPMBs）쌍모식성상효능급기연합초성대DLBCL미만대B세포림파류（ DLBCL）세포주SU-DHL-4증식화조망적영향。방법：이궤계진탕법제비공재아매소급초순자성양화철적MPMBs，관찰기체외증강B초、자공진현영적능력；장SU-DHL-4세포주안처리방법불동분조，CCK-8법검측각조세포활력，아정등／추화을정（ AO／EB ）쌍염법관찰세포형태。결과：MPMBs교보통고분자미포（ PMBs）구유경호적초성、자공진현영효과；MPMBs연합초성대DLBCL세포증식적억제강우기타처리조。결론：MPMBs시일충가집치료여초성、자공진성상우일체적다공능조영제。
Objective: To investigate the dual-mode imaging ability of multifunctional polymer microbubbles ( MPMBs) , and to observe its effect on cell proliferation and apoptosis in SU-DHL-4 cells.Methods:The MPMBs were made by mechanical vibration method .Enhancement of ultrasound ( US)/magnetic resonance ( MR) imaging were evaluated in vitro.The SU-DHL-4 cells were divided into several groups according to different treatments , then the viability of cells were measured by CCK-8 assay and the morphologic changes were detected by AO /EB staining.Results: US/MR dual-mode imaging showed its better property compared with ordinary polymer microbubbles(PMBs).Besides, anti-proliferation effect of MPMBs combined US on cells was much better than other treatment groups .Conclusion:The MPMBs can be served as a mutifunctional imaging agent for treatment and imaging.