CAJ | 학술논문

目的：利用血栓弹力图研究微炎症状态下持续性不卧床腹膜透析（ CAPD ）患者凝血功能的变化。方法：选择CAPD患者51例，根据C反应蛋白（ CRP ）水平分为CRP升高（＞8 mg · L－1）组和CRP正常（≤8 mg· L－1）组，对比分析两组血栓弹力图和常规凝血指标的变化。结果：与CRP正常组相比，CRP升高组血栓弹力图反应时间（R）和凝血时间（K）显著缩短（均P＜0．05），Angle（α角）、最大血块强度（MA）和综合凝血指数（CI）显著增加（均P＜0．05）。常规凝血指标在两组间差异无统计学意义（P＞0．05）。年龄和CRP与CI呈正相关（均P＜0．05）。多元线性回归分析提示，CRP是CI的独立危险因素（P＜0．05）。结论：与常规凝血指标相比，血栓弹力图是反映微炎症状态下CAPD患者高凝的一个更为灵敏的指标。
목적：이용혈전탄력도연구미염증상태하지속성불와상복막투석（ CAPD ）환자응혈공능적변화。방법：선택CAPD환자51례，근거C반응단백（ CRP ）수평분위CRP승고（＞8 mg · L－1）조화CRP정상（≤8 mg· L－1）조，대비분석량조혈전탄력도화상규응혈지표적변화。결과：여CRP정상조상비，CRP승고조혈전탄력도반응시간（R）화응혈시간（K）현저축단（균P＜0．05），Angle（α각）、최대혈괴강도（MA）화종합응혈지수（CI）현저증가（균P＜0．05）。상규응혈지표재량조간차이무통계학의의（P＞0．05）。년령화CRP여CI정정상관（균P＜0．05）。다원선성회귀분석제시，CRP시CI적독립위험인소（P＜0．05）。결론：여상규응혈지표상비，혈전탄력도시반영미염증상태하CAPD환자고응적일개경위령민적지표。
Objective: To investigate the changes of coagulative function in continuous ambulatory peritoneal dialysis ( CAPD) patients with micro-inflammatory state by thromboelastograph .Methods:Fifty-one CAPD patients were divided into two groups according to the level of C-reactive protein(CRP), the elevated(>8 mg· L-1) and normal(≤8 mg · L-1 ) CRP group.The parameters of thromboelastograph and conventional coagulation were compared between the two groups .Results: Compared with the normal CRP group , reactive time ( R ) and clot formation time(K) were significantly shortened(all P<0.05), while alpha angle(α), maximum amplitude(MA) and clot index ( CI ) were significantly increased ( all P <0.05 ) in elevated CRP group .The parameters of conventional coagulation had no statistical significance (P>0.05).Age and CRP were positively correlated with CI ( all P<0 .05 ) .Multivariate linear regression showed that CRP was an independent risk factor of CI ( all P <0.05) .Conclusions:Compared to conventional coagulation examinations , thromboelastograph is a more sensitive method to reveal the existence of hypercoagulation status in CAPD patients with micro-inflammatory state .