CAJ | 학술논문

目的：观察沙美特罗氟替卡松治疗支气管扩张伴气流受限患者的临床效果。方法选取支气管扩张伴气流受限患者51例，随机分为治疗组26例和对照组25例。两组患者均采用常规治疗，治疗组在常规治疗基础上给予长期规律吸入沙美特罗氟替卡松。分别测定两组治疗前、治疗4个月后临床症状指标、肺功能、痰中中性粒细胞百分比，并进行比较分析。结果两组患者治疗前临床症状指标、肺功能、痰中中性粒细胞百分比各项指标比较差异均无统计学意义（ P＞0.05）。治疗组治疗后临床症状指标、肺功能指标较治疗前明显改善（P＜0.05），痰中中性粒细胞百分比比治疗前明显降低（P＜0.05）；对照组各项指标改善不明显（P＞0.05）；两组治疗后比较差异有统计学意义（P＜0.05）。结论沙美特罗氟替卡松治疗支气管扩张伴气流受限患者，可改善临床症状及肺功能，降低痰中中性粒细胞百分比。
목적：관찰사미특라불체잡송치료지기관확장반기류수한환자적림상효과。방법선취지기관확장반기류수한환자51례，수궤분위치료조26례화대조조25례。량조환자균채용상규치료，치료조재상규치료기출상급여장기규률흡입사미특라불체잡송。분별측정량조치료전、치료4개월후림상증상지표、폐공능、담중중성립세포백분비，병진행비교분석。결과량조환자치료전림상증상지표、폐공능、담중중성립세포백분비각항지표비교차이균무통계학의의（ P＞0.05）。치료조치료후림상증상지표、폐공능지표교치료전명현개선（P＜0.05），담중중성립세포백분비비치료전명현강저（P＜0.05）；대조조각항지표개선불명현（P＞0.05）；량조치료후비교차이유통계학의의（P＜0.05）。결론사미특라불체잡송치료지기관확장반기류수한환자，가개선림상증상급폐공능，강저담중중성립세포백분비。
Objective To observe the curative effect of salmeterol fluticasone on patients with bronchiectasis and limited airflow.Methods 51 patients with bronchiectasis and limited airflow were randomly divided into treat-ment group(n=26) and control group(n=25).The two groups were treated with conventional treatment and the treatment group inhaled additional long-term salmeterol fluticasone regularly.Their clinical symptoms, pulmonary functions and sputum neutrophil percentages were observed and measured before and 4 months after the treatment.Re-sults The clinical symptoms, pulmonary functions and sputum neutrophil percentages had no significant differences between the two groups before the treatment(P>0.05).The clinical symptoms and the pulmonary function were im-proved significantly in the treatment group after the treatment, and the sputum neutrophil percentage was decreased obviously while there was no obvious change in the control group.Conclusion Salmeterol fluticasone can improve the clinical symptoms and lung function, reduce the sputum neutrophil percentage in patients with bronchiectasis and lim-ited airflow.