中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2015年
12期
35-37
,共3页
稳定型心绞痛%视黄醇结合蛋白4%Apelin-12%冠状动脉造影
穩定型心絞痛%視黃醇結閤蛋白4%Apelin-12%冠狀動脈造影
은정형심교통%시황순결합단백4%Apelin-12%관상동맥조영
Stable angina%Retinol binding protein 4%Apelin-12%Coronary angiography
目的 检测稳定型心绞痛患者血清视黄醇结合蛋白4(RBP4)和Apelin-12水平的变化,探讨其与冠状动脉狭窄程度、病变部位的关系.方法 以酶联免疫吸附法测定血清视黄醇结合蛋白4和Apelin-12水平;依据冠状动脉造影检查和Gensini评分结果分组.结果 与对照组比较,RBP4在GS1及GS2组中均显著高于对照组,Apelin-12显著低于对照组(P＜0.01).与对照组比较,RBP4在单支、双支、三支病变组中均高于对照组(P＜0.01),单支病变组与双支病变组比较差异无未见统计学意义(P＞0.05),但单支病变组与三支病变组比较差异有统计学意义(P＜0.01);Apelin-12在单支、双支及三支病变组之间比较差异均有统计学意义(P＜0.01).与对照组比较,RBP4在LAD病变组中高于对照组、Apelin-12在LAD病变组中显著低于对照组,两者在右冠状动脉病变组、回旋支病变组与对照组比较差异未见统计学意义(P＞0.05).结论 血清RBP4、Apelin-12水平和稳定型心绞痛患者冠脉病变狭窄程度有关,并且与冠状动脉病变部位有关.
目的 檢測穩定型心絞痛患者血清視黃醇結閤蛋白4(RBP4)和Apelin-12水平的變化,探討其與冠狀動脈狹窄程度、病變部位的關繫.方法 以酶聯免疫吸附法測定血清視黃醇結閤蛋白4和Apelin-12水平;依據冠狀動脈造影檢查和Gensini評分結果分組.結果 與對照組比較,RBP4在GS1及GS2組中均顯著高于對照組,Apelin-12顯著低于對照組(P＜0.01).與對照組比較,RBP4在單支、雙支、三支病變組中均高于對照組(P＜0.01),單支病變組與雙支病變組比較差異無未見統計學意義(P＞0.05),但單支病變組與三支病變組比較差異有統計學意義(P＜0.01);Apelin-12在單支、雙支及三支病變組之間比較差異均有統計學意義(P＜0.01).與對照組比較,RBP4在LAD病變組中高于對照組、Apelin-12在LAD病變組中顯著低于對照組,兩者在右冠狀動脈病變組、迴鏇支病變組與對照組比較差異未見統計學意義(P＞0.05).結論 血清RBP4、Apelin-12水平和穩定型心絞痛患者冠脈病變狹窄程度有關,併且與冠狀動脈病變部位有關.
목적 검측은정형심교통환자혈청시황순결합단백4(RBP4)화Apelin-12수평적변화,탐토기여관상동맥협착정도、병변부위적관계.방법 이매련면역흡부법측정혈청시황순결합단백4화Apelin-12수평;의거관상동맥조영검사화Gensini평분결과분조.결과 여대조조비교,RBP4재GS1급GS2조중균현저고우대조조,Apelin-12현저저우대조조(P＜0.01).여대조조비교,RBP4재단지、쌍지、삼지병변조중균고우대조조(P＜0.01),단지병변조여쌍지병변조비교차이무미견통계학의의(P＞0.05),단단지병변조여삼지병변조비교차이유통계학의의(P＜0.01);Apelin-12재단지、쌍지급삼지병변조지간비교차이균유통계학의의(P＜0.01).여대조조비교,RBP4재LAD병변조중고우대조조、Apelin-12재LAD병변조중현저저우대조조,량자재우관상동맥병변조、회선지병변조여대조조비교차이미견통계학의의(P＞0.05).결론 혈청RBP4、Apelin-12수평화은정형심교통환자관맥병변협착정도유관,병차여관상동맥병변부위유관.
Objective To detect the level change of RBP4 and Apelin-12 and to investigate the correlation of changes with coronary artery stenosis in patients with stable angina.Methods One hundred and eighteen patients who suffered stable angina with elective coronary angiography (CAG) were divided into two groups by gensini score(GS) system and the stenosis of each coronary artery was quantified:GS≤＜32(GS1) and GS2 ＞ 32 (GS2).Subgroups were divided based on the lesions of stenosis,the numbers and the locations of coronary artery diseased.Eighty six individuals with normal coronary angiography were selected as a control group.Enzyme linked immunosorbent assay(ELISA) was used to measure the plasma Apelin-12 and RBP4 levels.Results Compared with control group,Apelin-12 levels were decreased and RBP4 were elevated significantly in GS (P ＜0.01).Compared with control group,RBP4 in single,double,triple vessel disease group was higher (P ＜ 0.05);single,double vessel disease was no significant difference between the groups (P ＞ 0.05),but in single and three there was statistically significant difference (P ＜ 0.01).Apelin-12 in single,double and triple vessel disease,there were significant differences between the groups (P ＜ 0.01).Compared with control group,RBP4 was higher in the LAD lesion group,but Apelin-12 was lower in the LAD lesion group.In the RCA,LCX disease groups there were no statistically significant difference (P ＞ 0.05).Conclusions Concentration changes of Apelin-12 and RBP4 were induced by coronary atherosclerotic heart disease in stable angina based on the lesions,the numbers and the locations.
