中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2015年
12期
59-60
,共2页
小儿咳嗽变异性哮喘%酮替酚%孟鲁司特钠%疗效
小兒咳嗽變異性哮喘%酮替酚%孟魯司特鈉%療效
소인해수변이성효천%동체분%맹로사특납%료효
Cough variant asthma%Ketotifen%Montelukast%Curative effect
目的 观察比较小儿咳嗽变异性哮喘采用孟鲁司特钠与酮替酚治疗的远期疗效及近期疗效.方法 选取收治的72例小儿咳嗽变异性哮喘患者作为观察对象,将其按照随机的方式分为两组,观察组36例患儿采用孟鲁司特钠治疗,对照组36例患儿采用酮替酚治疗,两组患儿均随访6个月,对两组患者的近期疗效及远期疗效进行观察和比较.结果 经治疗8周,观察组患儿有33例为治疗有效,临床治疗总有效率达到91.7％,对照组有25例为治疗有效,其总有效率为69.4％,两组患者近期疗效对比观察组明显优于对照组,差异有统计学意义(P＜0.05).经随访6个月,观察组有1例复发,对照组有6例复发,观察组复发率明显更低且复发时间明显更长(P＜0.05).结论 小儿咳嗽变异性哮喘采用孟鲁司特钠治疗疗效确切,与酮替酚治疗相比较其近远期疗效均更佳,具有较高的安全性和可行性,值得应用和推广.
目的 觀察比較小兒咳嗽變異性哮喘採用孟魯司特鈉與酮替酚治療的遠期療效及近期療效.方法 選取收治的72例小兒咳嗽變異性哮喘患者作為觀察對象,將其按照隨機的方式分為兩組,觀察組36例患兒採用孟魯司特鈉治療,對照組36例患兒採用酮替酚治療,兩組患兒均隨訪6箇月,對兩組患者的近期療效及遠期療效進行觀察和比較.結果 經治療8週,觀察組患兒有33例為治療有效,臨床治療總有效率達到91.7％,對照組有25例為治療有效,其總有效率為69.4％,兩組患者近期療效對比觀察組明顯優于對照組,差異有統計學意義(P＜0.05).經隨訪6箇月,觀察組有1例複髮,對照組有6例複髮,觀察組複髮率明顯更低且複髮時間明顯更長(P＜0.05).結論 小兒咳嗽變異性哮喘採用孟魯司特鈉治療療效確切,與酮替酚治療相比較其近遠期療效均更佳,具有較高的安全性和可行性,值得應用和推廣.
목적 관찰비교소인해수변이성효천채용맹로사특납여동체분치료적원기료효급근기료효.방법 선취수치적72례소인해수변이성효천환자작위관찰대상,장기안조수궤적방식분위량조,관찰조36례환인채용맹로사특납치료,대조조36례환인채용동체분치료,량조환인균수방6개월,대량조환자적근기료효급원기료효진행관찰화비교.결과 경치료8주,관찰조환인유33례위치료유효,림상치료총유효솔체도91.7％,대조조유25례위치료유효,기총유효솔위69.4％,량조환자근기료효대비관찰조명현우우대조조,차이유통계학의의(P＜0.05).경수방6개월,관찰조유1례복발,대조조유6례복발,관찰조복발솔명현경저차복발시간명현경장(P＜0.05).결론 소인해수변이성효천채용맹로사특납치료료효학절,여동체분치료상비교기근원기료효균경가,구유교고적안전성화가행성,치득응용화추엄.
Objective To observe and compare the short term and long term effect of montelukast and ketotifen on children with cough variant asthma.Methods Seventy-two children with cough variant asthma were selected as observation objects.All the patients were randomly divided into two groups,36 cases in observation group were given montelukast sodium,36 cases in control group were treated with ketotifen treatment.The patients were followed up for 6 months.The short-term and long-term therapeutic effects were observed and compared.Results After 8 weeks of treatment,33 cases were effective in the observation group,the total effective rate reached 91.7％.In control group,25 cases were effective,the total effective rate was 69.4％.The short-term curative effect in observation group was obviously superior to that in the control group,there was significant difference (P ＜ 0.05).After 6 months of follow-up,the observation group had 1 case of reccurence,the control group had 6 cases of recurrence.The recurrence rate of observation group was significantly lower than that of the control group,and the recurrence time was significantly longer than that of the control group (P ＜ 0.05).Conclusions The curative effect of montelukast sodium on children with cough variant asthma is good,has better short-term and long-term therapeutic effects than ketotifen,and has high safety and feasibility,so it is worth of application and promotion.
