中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2015年
12期
53-54
,共2页
沙利度胺%CAG方案%老年急性髓系白血病
沙利度胺%CAG方案%老年急性髓繫白血病
사리도알%CAG방안%노년급성수계백혈병
Thalidomide%CAG regiment%Elderly acute myeloid leukemia
目的 探讨沙利度胺联合CAG方案用于老年人急性髓性白血病治疗的临床疗效.方法 选取襄城县人民医院2008年4月至2012年6月52例老年急性髓系白血病患者,随机分为对照组和观察组,每组26例.对照组采用CAG方案,观察组在对照组基础上增加沙利度胺,比较两组临床疗效、生存率、平均生存时间及不良反应发生率.结果 观察组总有效率(80.77％)高于对照组(53.83％),2年生存率(46.15％)高于对照组(19.23％),平均生存时间为(21.8±3.6)个月,长于对照组的(13.4±3.1)个月,恶心呕吐不良反应发生率(38.46％)低于对照组(57.69％),各项组间比较差异均有统计学意义(P＜0.05);两组血液学不良反应发生率组间比较差异未见统计意义(P＞0.05).结论 沙利度胺联合CAG方案治疗老年人急性髓系白血病疗效好,不良反应较轻,应在临床中进一步研究和推广应用.
目的 探討沙利度胺聯閤CAG方案用于老年人急性髓性白血病治療的臨床療效.方法 選取襄城縣人民醫院2008年4月至2012年6月52例老年急性髓繫白血病患者,隨機分為對照組和觀察組,每組26例.對照組採用CAG方案,觀察組在對照組基礎上增加沙利度胺,比較兩組臨床療效、生存率、平均生存時間及不良反應髮生率.結果 觀察組總有效率(80.77％)高于對照組(53.83％),2年生存率(46.15％)高于對照組(19.23％),平均生存時間為(21.8±3.6)箇月,長于對照組的(13.4±3.1)箇月,噁心嘔吐不良反應髮生率(38.46％)低于對照組(57.69％),各項組間比較差異均有統計學意義(P＜0.05);兩組血液學不良反應髮生率組間比較差異未見統計意義(P＞0.05).結論 沙利度胺聯閤CAG方案治療老年人急性髓繫白血病療效好,不良反應較輕,應在臨床中進一步研究和推廣應用.
목적 탐토사리도알연합CAG방안용우노년인급성수성백혈병치료적림상료효.방법 선취양성현인민의원2008년4월지2012년6월52례노년급성수계백혈병환자,수궤분위대조조화관찰조,매조26례.대조조채용CAG방안,관찰조재대조조기출상증가사리도알,비교량조림상료효、생존솔、평균생존시간급불량반응발생솔.결과 관찰조총유효솔(80.77％)고우대조조(53.83％),2년생존솔(46.15％)고우대조조(19.23％),평균생존시간위(21.8±3.6)개월,장우대조조적(13.4±3.1)개월,악심구토불량반응발생솔(38.46％)저우대조조(57.69％),각항조간비교차이균유통계학의의(P＜0.05);량조혈액학불량반응발생솔조간비교차이미견통계의의(P＞0.05).결론 사리도알연합CAG방안치료노년인급성수계백혈병료효호,불량반응교경,응재림상중진일보연구화추엄응용.
Objective To investigate the clinical efficacy of thalidomide combined with CAG regiment on elderly acute myeloid leukemia.Methods Fifty-two patients with elderly acute myeloid leukemia in people' s hospital of Xiangcheng from April 2008 to June 2012 were divided into the control group and observation group,with 26 cases in each group.The control group was treated by CAG regiment and the observation group was conducted with thalidomide besides CAG regiment.The clinical efficacy,survival,mean survival time and incidence of adverse reactions of two groups were analyzed.Results The total effective rate of observation group(80.77％) was higher than that of the control group (53.83％);two years survival rate (46.15％) was higher than that of the control group (19.23％);the average survival time [(21.8 ±3.6) months] was longer than that of the control group [(13.4 ±3.1) months],nausea and vomiting incidence of adverse reactions (38.46％) was lower than those of control group (57.69％) (P ＜ 0.05).The incidence of adverse reactions of patients with hematology had no significant difference (P ＞ 0.05).Conclusions The thalidomide combined with CAG regiment in treatment of elderly acute myeloid leukemia has better clinical efficacy and lesser side effects,so it is worthy of further research and application in clinics.
