CAJ | 학술논문

目的观察脑胶质瘤患者手术前后睾酮水平及其变化,并探讨其临床意义.方法采用微粒子化学发光免疫分析方法检测实验组(脑胶质瘤病例组)及对照组(颅内良性肿瘤、功能性疾病等病例组)术前、术后静脉血睾酮水平,两组均进行开颅手术.结果脑胶质瘤患者血清睾酮水平[男性:(15.25±4.68) nmol/L、女性:(1.17 ±0.59) nmol/L]明显高于颅内良性肿瘤或功能性神经疾病患者[男性:(10.81±2.51)nmol/L、女性:(0.42±0.34) nmol/L],脑胶质瘤手术后3～4d睾酮水平下降程度[男性:(8.62±4.66) nmol/L、女性:(0.55 ±0.13) nmol/L]较功能性神经疾病或颅内良性肿瘤患者明显[男性:(3.79±2.66) nmol/L、女性:(-0.45 ±0.12)nmol/L],且差异有统计学意义(P＜0.05).脑胶质瘤组术后6～9d血清睾酮水平变化与术后3～4 d差异无统计学意义(P＞0.05).睾酮水平及其变化与胶质瘤密切相关,但与脑胶质瘤病理级别无相关性.脑胶质瘤患者血清睾酮水平均较颅内其他肿瘤和功能性神经疾病的血清睾酮浓度高,差异有统计学意义.手术切除肿瘤后,胶质瘤组睾酮水平较术前明显减低;而在对照组,手术后睾酮水平稍降低,很快又恢复至术前水平.结论脑胶质瘤患者血清中存在睾酮代谢失衡与紊乱.
목적 관찰뇌효질류환자수술전후고동수평급기변화,병탐토기림상의의.방법 채용미입자화학발광면역분석방법검측실험조(뇌효질류병례조)급대조조(로내량성종류、공능성질병등병례조)술전、술후정맥혈고동수평,량조균진행개로수술.결과 뇌효질류환자혈청고동수평[남성:(15.25±4.68) nmol/L、녀성:(1.17 ±0.59) nmol/L]명현고우로내량성종류혹공능성신경질병환자[남성:(10.81±2.51)nmol/L、녀성:(0.42±0.34) nmol/L],뇌효질류수술후3～4d고동수평하강정도[남성:(8.62±4.66) nmol/L、녀성:(0.55 ±0.13) nmol/L]교공능성신경질병혹로내량성종류환자명현[남성:(3.79±2.66) nmol/L、녀성:(-0.45 ±0.12)nmol/L],차차이유통계학의의(P＜0.05).뇌효질류조술후6～9d혈청고동수평변화여술후3～4 d차이무통계학의의(P＞0.05).고동수평급기변화여효질류밀절상관,단여뇌효질류병리급별무상관성.뇌효질류환자혈청고동수평균교로내기타종류화공능성신경질병적혈청고동농도고,차이유통계학의의.수술절제종류후,효질류조고동수평교술전명현감저;이재대조조,수술후고동수평초강저,흔쾌우회복지술전수평.결론 뇌효질류환자혈청중존재고동대사실형여문란.
Objective To investigate the change of serum testosterone in patients with glioma.Methods The serum level of testosterone in glioma group and control group before and after operation were measured by chemical immunofluorescence technique.All the patients in these two groups were performed craniotomy operation.Results The serum level of testosterone in glioma patients [male (15.25 ± 4.68) nmol/L,female (1.17 ±0.59) nmol/L] was significantly higher than that in patients with benign tumors or functional diseases [male (10.81 ± 2.51) nmol/L,female (0.42 ± 0.34) nmol/L].Three or four days later after operation,the reduction of serum testosterone was more obvious in glioma patients [male (8.62 ±4.66) nmol/L,female (0.55 ±0.13) nmol/L] than that in control group [male (3.79 ± 2.66) nmol/L,female (-0.45 ±0.12) nmol/L] (P ＜0.05).The change of testosterone in 6-9 days after operation compared to the change in 3-4 days after operation showed no statistical significance in glioma group (P ＞ 0.05).However,there was no significant difference of the level of testosterone before and after operation in patients with different WHO grade of glioma.Conclusion It is significant that the serum testosterone level is higher in patients with glioma than that in patients with benign tumor or functional diseases group.After removing the tumor,the serum testosterone level decrease more than than in the control group.However,in the control group,the level of testoterone recover soom after sugery.So we can conclude that there are disorders and imbalances of testosterone metabolism in patients with glioma.