中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2015年
6期
1434-1436
,共3页
齐博%卢家彬%赵宝生%李汉臣
齊博%盧傢彬%趙寶生%李漢臣
제박%로가빈%조보생%리한신
食管鳞状细胞癌%角化细胞生长因子%存活素
食管鱗狀細胞癌%角化細胞生長因子%存活素
식관린상세포암%각화세포생장인자%존활소
Esophageal squamous cell carcinoma%Keratinocyte growth factor%Survivin
目的 观察食管鳞状细胞癌(ESCC)中角化细胞生长因子(KGF)和存活素(Survivin)的表达,探讨其与患者临床病理特征之间的关系.方法 采用免疫组织化学法对56例ESCC手术切除标本(ESCC组)、30例ESCC切除标本上、下断端(距肿瘤边缘＞5 cm)的正常食管上皮(对照组)石蜡标本组织切片进行染色,并观察、评定KGF和Survivin蛋白表达水平.分析KGF、Suwivin蛋白的表达与标本来源患者临床病理指标的关系.结果 ESCC组KGF和Survivin蛋白的表达水平(1.09±0.03、0.25 ±0.11)均显著高于对照组(4.11±1.27、0.36±0.08),其差异有统计学意义(P＜0.05).KGF蛋白的表达与有无淋巴结转移及分化程度明显相关(P＜0.05).Survivin的表达与有无淋巴结转移明显相关(P＜0.05).ECSS组织中KGF与Survivin表达呈正相关(r=0.873,P＜0.05).结论 KGF和Survivin可能在ESCC的发生、发展中起重要作用.
目的 觀察食管鱗狀細胞癌(ESCC)中角化細胞生長因子(KGF)和存活素(Survivin)的錶達,探討其與患者臨床病理特徵之間的關繫.方法 採用免疫組織化學法對56例ESCC手術切除標本(ESCC組)、30例ESCC切除標本上、下斷耑(距腫瘤邊緣＞5 cm)的正常食管上皮(對照組)石蠟標本組織切片進行染色,併觀察、評定KGF和Survivin蛋白錶達水平.分析KGF、Suwivin蛋白的錶達與標本來源患者臨床病理指標的關繫.結果 ESCC組KGF和Survivin蛋白的錶達水平(1.09±0.03、0.25 ±0.11)均顯著高于對照組(4.11±1.27、0.36±0.08),其差異有統計學意義(P＜0.05).KGF蛋白的錶達與有無淋巴結轉移及分化程度明顯相關(P＜0.05).Survivin的錶達與有無淋巴結轉移明顯相關(P＜0.05).ECSS組織中KGF與Survivin錶達呈正相關(r=0.873,P＜0.05).結論 KGF和Survivin可能在ESCC的髮生、髮展中起重要作用.
목적 관찰식관린상세포암(ESCC)중각화세포생장인자(KGF)화존활소(Survivin)적표체,탐토기여환자림상병리특정지간적관계.방법 채용면역조직화학법대56례ESCC수술절제표본(ESCC조)、30례ESCC절제표본상、하단단(거종류변연＞5 cm)적정상식관상피(대조조)석사표본조직절편진행염색,병관찰、평정KGF화Survivin단백표체수평.분석KGF、Suwivin단백적표체여표본래원환자림상병리지표적관계.결과 ESCC조KGF화Survivin단백적표체수평(1.09±0.03、0.25 ±0.11)균현저고우대조조(4.11±1.27、0.36±0.08),기차이유통계학의의(P＜0.05).KGF단백적표체여유무림파결전이급분화정도명현상관(P＜0.05).Survivin적표체여유무림파결전이명현상관(P＜0.05).ECSS조직중KGF여Survivin표체정정상관(r=0.873,P＜0.05).결론 KGF화Survivin가능재ESCC적발생、발전중기중요작용.
Objective To investigate the expression of keratinocyte growth factor (KGF) and survivin in human esophageal squamous cell carcinoma (ESCC),and its relationship with clinicopathologic factors of patients with ESCC.Methods Fifty-six cases of surgically resected specimens from ESCC (ESCC gruoup) and 30 cases of normal esophageal epithelia from the broken ends of excisional specimens (the distance to tumor border ＞ 5 cm,control group) were selected for immunohistochemical staining of KGF and survivin expression levels.The relationship of KGF and survivin expression with the clinicopathological features was analyzed.Results The expression levels of KGF and survivin in ESCC group (1.09 ± 0.03,and 0.25 ± 0.11) were higher significantly than those in control group (4.11 ± 1.27,and 0.36 ± 0.08,P ＜0.05).The expression of KGF in ECSS was correlated with lymph node metastasis and the tumor differentiation degrees (P ＜ 0.05).The expression of survivin in ECSS was correlated with lymph node metastasis (P ＜ 0.05).There was a positive correlation between KGF and survivin expression in ECSS tissues (r =0.873,P ＜ 0.05).Conclusion KGF and survivin may play important roles in the carcinogenesis and development of ESCC.
