CAJ | 학술논문

代谢组学是继基因组学、转录组学和蛋白质组学之后迅速兴起的系统生物学的一个重要分支。它通过组群指标分析，进行高通量检测和数据处理，对生物体内的小分子代谢物进行动态的定性定量分析，可灵敏地发现由毒物作用引起的异常代谢变化，获得毒物毒性效应、作用机制和生物标记物的信息。本文从代谢组学在滥用药物、农药和有毒动植物毒理学研究的应用等方面进行综述，阐述这一法医毒理学研究的新方向。
대사조학시계기인조학、전록조학화단백질조학지후신속흥기적계통생물학적일개중요분지。타통과조군지표분석，진행고통량검측화수거처리，대생물체내적소분자대사물진행동태적정성정량분석，가령민지발현유독물작용인기적이상대사변화，획득독물독성효응、작용궤제화생물표기물적신식。본문종대사조학재람용약물、농약화유독동식물독이학연구적응용등방면진행종술，천술저일법의독이학연구적신방향。
Metabonom ics is an im portant branch of system biology follow ing the developm ent of ge-nom ics, transcriptom ics and proteom ics. It can perform high-throughput detection and data processing with multiple param eters, potentially enabling the identification and quantification of all sm all m etabolites in a biological system . It can be used to provide com prehensive inform ation on the toxicity effects, toxi-cological mechanisms and biom arkers, sensitively finding the unusual m etabolic changes caused by poi-son. This article mainly review s application of m etabonom ics in toxicological studies of abused drugs, pesticides, poisonous plants and poisonous anim als, and also illustrates the new direction of forensic toxi-cology research.