中国临床新医学
中國臨床新醫學
중국림상신의학
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
2015年
6期
500-503
,共4页
慢性重症乙型肝炎%谷胺酰胺%肝功能%内毒素血症
慢性重癥乙型肝炎%穀胺酰胺%肝功能%內毒素血癥
만성중증을형간염%곡알선알%간공능%내독소혈증
Severe chronic hepatitis B%Glutamine%Liver function%Endotoxemia
目的:观察慢性重症乙型肝炎患者应用小剂量谷胺酰胺颗粒后肝功能和内毒素水平的临床变化,评价小剂量谷胺酰胺颗粒应用于慢性重症乙型肝炎患者的可行性。方法40例诊断慢性重症乙型肝炎明确的患者随机分为对照组和治疗组。对照组给予常规护肝、抗病毒和支持治疗;治疗组在对照组治疗的基础上加用小剂量谷胺酰胺颗粒5 g,tid,疗程均为14 d。观察两组慢性重症乙型肝炎患者治疗前后肝功能和内毒素水平的变化,并进行组间和组内对比分析。结果两组患者治疗前后对比,肝功能和内毒素水平均有所改善(P<0.01),但加用小剂量谷胺酰胺颗粒5 g,tid后,治疗组与对照组相比,肝功能和内毒素水平均无明显变化( P>0.05)。结论在慢性重症乙型肝炎患者治疗中加用小剂量谷胺酰胺颗粒未能起到进一步改善肝功能及内毒素血症的临床作用。
目的:觀察慢性重癥乙型肝炎患者應用小劑量穀胺酰胺顆粒後肝功能和內毒素水平的臨床變化,評價小劑量穀胺酰胺顆粒應用于慢性重癥乙型肝炎患者的可行性。方法40例診斷慢性重癥乙型肝炎明確的患者隨機分為對照組和治療組。對照組給予常規護肝、抗病毒和支持治療;治療組在對照組治療的基礎上加用小劑量穀胺酰胺顆粒5 g,tid,療程均為14 d。觀察兩組慢性重癥乙型肝炎患者治療前後肝功能和內毒素水平的變化,併進行組間和組內對比分析。結果兩組患者治療前後對比,肝功能和內毒素水平均有所改善(P<0.01),但加用小劑量穀胺酰胺顆粒5 g,tid後,治療組與對照組相比,肝功能和內毒素水平均無明顯變化( P>0.05)。結論在慢性重癥乙型肝炎患者治療中加用小劑量穀胺酰胺顆粒未能起到進一步改善肝功能及內毒素血癥的臨床作用。
목적:관찰만성중증을형간염환자응용소제량곡알선알과립후간공능화내독소수평적림상변화,평개소제량곡알선알과립응용우만성중증을형간염환자적가행성。방법40례진단만성중증을형간염명학적환자수궤분위대조조화치료조。대조조급여상규호간、항병독화지지치료;치료조재대조조치료적기출상가용소제량곡알선알과립5 g,tid,료정균위14 d。관찰량조만성중증을형간염환자치료전후간공능화내독소수평적변화,병진행조간화조내대비분석。결과량조환자치료전후대비,간공능화내독소수평균유소개선(P<0.01),단가용소제량곡알선알과립5 g,tid후,치료조여대조조상비,간공능화내독소수평균무명현변화( P>0.05)。결론재만성중증을형간염환자치료중가용소제량곡알선알과립미능기도진일보개선간공능급내독소혈증적림상작용。
Objective To study the effect of low dose glutamin on liver function and endotoxemia in severe chronic hepatitis B patients.Methods Forty patients with severe chronic hepatitis B were randomly divided into the control group and the experiment group.The control group received the conventional treatment and the experiment group received addiontional glutamine treatment(5 g tid).The period of the treatment is two weeks.ALT, AST, TBIL, PT, A, CHE and endotoxin( ET) were detected before and after treatment in the two groups respectively.Re-sults The liver function and serum ET were both improved significantly after two weeks′treatment, compared with those before treatment in the two groups(P<0.01).Both of the two parameters had no significant difference between the two groups after the treatment(P>0.05).Conclusion Adding low dose glutamine(5 g tid) to the conventional treatment can not ameliorate the endotoxemia and liver function in patients with severe chronic hepatitis B.