CAJ | 학술논문

目的：探讨利奈唑胺在ICU重症感染患者中应用的有效性及安全性。方法对入住ICU的27例重症感染患者给予利奈唑胺0.6 g，2次／d，观察用药前和用药72 h后的体温、血常规、肝肾功能等指标的变化并进行对比分析，以评价药物的有效性及安全性。结果27例患者中19例好转，8例死亡或自动出院，临床有效率为70.37％。使用利奈唑胺72 h后，患者体温血象均较前下降，血小板计数稍有下降，肝肾功能无明显变化，所观察的指标治疗前后差异无统计学意义（ P＞0.05）。结论利奈唑胺在重症感染患者中短期应用是安全有效的，长期应用的药物副作用需要进一步观察。
목적：탐토리내서알재ICU중증감염환자중응용적유효성급안전성。방법대입주ICU적27례중증감염환자급여리내서알0.6 g，2차／d，관찰용약전화용약72 h후적체온、혈상규、간신공능등지표적변화병진행대비분석，이평개약물적유효성급안전성。결과27례환자중19례호전，8례사망혹자동출원，림상유효솔위70.37％。사용리내서알72 h후，환자체온혈상균교전하강，혈소판계수초유하강，간신공능무명현변화，소관찰적지표치료전후차이무통계학의의（ P＞0.05）。결론리내서알재중증감염환자중단기응용시안전유효적，장기응용적약물부작용수요진일보관찰。
Objective To analyze the clinical efficacy and safety of linezolid in the treatment of severe sepsis in intensive care unit.Methods Twenty-seven patients with severe sepsis were treated with linezolid 0.6 gram twice per day and the blood routine examination, liver and renal function were tested before and 72 h after the medication to analyze the efficiency and safety of the treatment.Results The clinical efficacy rate was 70.37%, and there were no significant differences in the blood routine examination, liver and renal function before and after 72 hours′treatment of linezolid(P>0.05).Conclusion Linezolid has conspicuous effectiveness and safety in the treatment of severe sep-sis within 72 h in intensive care unit.