CAJ | 학술논문

目的：探讨SLC30A8基因rs13266634 C/T单核苷酸多态性（SNP）与锦州地区2型糖尿病（T2DM）易感性之间的相关性。方法基于病例?对照分析，采用聚合酶链反应（PCR）?高分辨率溶解曲线（HRM）方法对锦州地区136例2型糖尿病患者（T2DM组）和145例健康对照（NC组）SLC30A8基因rs13266634位点的单核苷酸多态性进行检测。结果 CC基因型频率T2DM组（38.23%）高于NC组（22.07%）；C等位基因频率T2DM组（61.76%）高于NC组（51.03%），差异均具有统计学意义（P<0.05）；等位基因C增加了2型糖尿病1.550倍患病风险（OR=1.550，95%CI：1.108~2.169，P<0.05）。结论 SLC30A8基因rs13266634 C/T单核苷酸多态性与锦州地区T2DM的发病相关，C是风险等位基因。
목적：탐토SLC30A8기인rs13266634 C/T단핵감산다태성（SNP）여금주지구2형당뇨병（T2DM）역감성지간적상관성。방법기우병례?대조분석，채용취합매련반응（PCR）?고분변솔용해곡선（HRM）방법대금주지구136례2형당뇨병환자（T2DM조）화145례건강대조（NC조）SLC30A8기인rs13266634위점적단핵감산다태성진행검측。결과 CC기인형빈솔T2DM조（38.23%）고우NC조（22.07%）；C등위기인빈솔T2DM조（61.76%）고우NC조（51.03%），차이균구유통계학의의（P<0.05）；등위기인C증가료2형당뇨병1.550배환병풍험（OR=1.550，95%CI：1.108~2.169，P<0.05）。결론 SLC30A8기인rs13266634 C/T단핵감산다태성여금주지구T2DM적발병상관，C시풍험등위기인。
Objective To investigate the correlation between the rs13266634 C/T SNP of SLC30A8 and T2DM in Jinzhou. Methods Based on case?control study,PCR?HRM was used to identify the genotypes of rs13266634 of SLC30A8 gene in 136 cases of T2DM patients and 145 cases of healthy control in Jinzhou. Results The CC genotypic frequency and C allele frequency in T2DM(38.23%and 61.76%)were higher than those of healthy control(22.07%and 51.03%). Furthermore,there was significant difference in case?control study from the population in Jinzhou(P<0.05). The odds ratio of allele C for T2DM was 1.550(95%CI:1.108?2.169,P<0.05). Conclusion The single nucleotide polymorphism of the rs13266634 locus in SLC30A8gene was correlated with T2DM susceptibility in Jinzhou,and the allele C was a risk allele.