实用皮肤病学杂志
實用皮膚病學雜誌
실용피부병학잡지
JOURNAL OF PRACTRCAL DERMATOLOGY
2015年
3期
201-204
,共4页
皮炎,接触性,变应性%T细胞,调节性%皮肤超敏反应%免疫
皮炎,接觸性,變應性%T細胞,調節性%皮膚超敏反應%免疫
피염,접촉성,변응성%T세포,조절성%피부초민반응%면역
Dermatitis,contact,allergic%T cells,regulatory%Cutaneous hypersensitivity%Immunity
调节性T细胞是一类具有免疫调节作用的T细胞亚群。近年来研究发现调节性T细胞除了CD4+CD25+Foxp3+T细胞外，还有多种亚型，通过多种免疫调节机制作用于效应细胞和抗原提呈细胞发挥免疫抑制作用，参与机体多种炎症和自身免疫相关疾病。变应性接触性皮炎是一种常见的炎症性皮肤病，是抗原特异性T细胞介导的皮肤超敏反应。调节性T细胞通过多种免疫调节通路，在其致敏阶段和诱发阶段均发挥重要作用，从而阻止弱抗原引发的接触性皮炎，减弱强抗原引发的皮肤炎症反应。
調節性T細胞是一類具有免疫調節作用的T細胞亞群。近年來研究髮現調節性T細胞除瞭CD4+CD25+Foxp3+T細胞外，還有多種亞型，通過多種免疫調節機製作用于效應細胞和抗原提呈細胞髮揮免疫抑製作用，參與機體多種炎癥和自身免疫相關疾病。變應性接觸性皮炎是一種常見的炎癥性皮膚病，是抗原特異性T細胞介導的皮膚超敏反應。調節性T細胞通過多種免疫調節通路，在其緻敏階段和誘髮階段均髮揮重要作用，從而阻止弱抗原引髮的接觸性皮炎，減弱彊抗原引髮的皮膚炎癥反應。
조절성T세포시일류구유면역조절작용적T세포아군。근년래연구발현조절성T세포제료CD4+CD25+Foxp3+T세포외，환유다충아형，통과다충면역조절궤제작용우효응세포화항원제정세포발휘면역억제작용，삼여궤체다충염증화자신면역상관질병。변응성접촉성피염시일충상견적염증성피부병，시항원특이성T세포개도적피부초민반응。조절성T세포통과다충면역조절통로，재기치민계단화유발계단균발휘중요작용，종이조지약항원인발적접촉성피염，감약강항원인발적피부염증반응。
Regulatory T cells (Tregs) are a subset of T cells with immunoregulation activities. Recent studies have found that Tregs, apart from CD4+CD25+Foxp3+Tregs, play strong immunosuppression effects in the maintenance of self-tolerance and immune homeostasis, mainly by acting on effector cells and antigen presenting cells (APC) through multiple immunoregulatory pathways. Allergic contact dermatitis (ACD) is a common inflammatory skin disease, and also referred to as cutaneous hypersensitivity, is mediated by antigen-speciifc T cells. Tregs take an important part in allergic contact dermatitis, including preventing a weak hapten-induced contact dermatitis and reducing a strong hapten-induced cutaneous inlfammation reaction.
