CAJ | 학술논문

骨髓间充质干细胞（ bone marrow stem cell ， BMSC ）是一种具有多向分化潜能的成体干细胞，适量的力学刺激能促进BMSC向成骨细胞分化。近几年来，一些学者利用力学刺激作用于体外培养的BMSC，促进其向成骨细胞分化，并且对其诱导分化的机制进行了大量研究。尽管这一机制目前尚不十分清楚，但是已有的研究表明，多条信号通路参与了该力学信号传导。本文就国内外近几年来关于力学信号影响BMSC成骨分化的信号转导机制研究进展做一综述。
골수간충질간세포（ bone marrow stem cell ， BMSC ）시일충구유다향분화잠능적성체간세포，괄량적역학자격능촉진BMSC향성골세포분화。근궤년래，일사학자이용역학자격작용우체외배양적BMSC，촉진기향성골세포분화，병차대기유도분화적궤제진행료대량연구。진관저일궤제목전상불십분청초，단시이유적연구표명，다조신호통로삼여료해역학신호전도。본문취국내외근궤년래관우역학신호영향BMSC성골분화적신호전도궤제연구진전주일종술。
Bone marrow stem cells ( BMSC ) are multipotent adult stem cells with mechanosensitive property.Mechanical stimuli can promote the osteogenic differenitiation of BMSC . In recent years , many studies have been focused on the mechanism for osteogenic differentiation of BMSC although it is not completely clear.It has been reported that several signal pathways are involved in the mechanotransduction of BMSC responding to mechanical stimuli . This review focuses on the advances of recent researches about the mechanism of osteogenic differentiation induced by mechanical stimulation .