CAJ | 학술논문

目的：探讨细胞角蛋白21‐1（CYFRA21‐1）、糖类抗原‐125（CA125）、人乳头瘤病毒（HPV）检测联合新柏氏液基细胞学检查（TCT）在宫颈癌诊断的临床价值。方法选取宫颈癌患者70例，宫颈良性疾病60例和同期检查的健康者70例作为健康组，对3组人群CYFRA21‐1、CA125、HPV检测与TCT结果进行分析。结果 HPV、TCT、CA125与CYFRA21‐1在宫颈癌患者中检出阳性率明显高于宫颈良性病变组和健康组，差异有统计学意义（P＜0．01）；HPV、TCT、CA125与CYFRA21‐1诊断宫颈癌的敏感度从大到小依次为 TCT、CYFRA21‐1、CA125、HPV ，特异度从高到低分别是 CYFRA21‐1、TCT、CA125、HPV。 HPV、TCT、CA125与CYFRA21‐1进行并联诊断试验中敏感度高达100．00％，在串联诊断试验中特异度高达98．3％。结论 HPV、CA125、CYFRA21‐1检测与TCT联合诊断宫颈癌具有较强的可靠性，临床上值得推广使用。
목적：탐토세포각단백21‐1（CYFRA21‐1）、당류항원‐125（CA125）、인유두류병독（HPV）검측연합신백씨액기세포학검사（TCT）재궁경암진단적림상개치。방법선취궁경암환자70례，궁경량성질병60례화동기검사적건강자70례작위건강조，대3조인군CYFRA21‐1、CA125、HPV검측여TCT결과진행분석。결과 HPV、TCT、CA125여CYFRA21‐1재궁경암환자중검출양성솔명현고우궁경량성병변조화건강조，차이유통계학의의（P＜0．01）；HPV、TCT、CA125여CYFRA21‐1진단궁경암적민감도종대도소의차위 TCT、CYFRA21‐1、CA125、HPV ，특이도종고도저분별시 CYFRA21‐1、TCT、CA125、HPV。 HPV、TCT、CA125여CYFRA21‐1진행병련진단시험중민감도고체100．00％，재천련진단시험중특이도고체98．3％。결론 HPV、CA125、CYFRA21‐1검측여TCT연합진단궁경암구유교강적가고성，림상상치득추엄사용。
Objective To investigate the value of cytokeratin fragment antigen 21‐1(CYFRA21‐1) ,carbohydrate antigen‐125 (CA125) ,human papillomavirus (HPV ) detection with Thinprep cytologic test (TCT ) in the diagnosis of cervical cancer . Methods 70 patients with cervical cancer ,60 patients with benign cervical diseases and 70 healthy people were selected .CYFRA21‐1 ,CA125 ,HPV detection and TCT results were analyzed .Results The positive rates of HPV ,TCT ,CA125 and CYFRA21‐1 in cervical cancer group were significantly higher than those in cervical benign lesion group and the healthy group ,the difference were statistically significant (P< 0 .01);The sensitivity of HPV ,TCT ,CA125 and CYFRA21‐1 in diagnosis of cervical cancer was CA125> TSGF>CEA>SIL‐2R .The specificity was CYFRA21‐1> TCT>CA125> HPV .In HPV ,TCT ,CA125 and CYFRA21‐1parallel diagnostic test ,the sensitivity was up to 100 .00% ,and in series diagnostic test ,the specificity was up to 98 .3% .Conclu‐sion HPV ,CA125 ,CYFRA21‐1 detection combined with TCT in diagnosis of cervical cancer has strong reliability ,it is worth u‐sing w idely in clinic .