CAJ | 학술논문

目的：探讨MRI在氩氦刀冷冻治疗前列腺癌术后疗效评价中的价值。方法系统回顾2012年3月—2014年10月16例超声引导下氩氦刀冷冻治疗前列腺癌的临床及影像资料，分析术前术后实验室指标的变化，对比术前术后 MRI 资料，观察消融效果，包括有无术后残留、转移等。结果术后1个月MRI 提示所有患者冷冻消融范围满意，均表现为长T2信号，DWI及DCE-MRI未见明显异常复发，前列腺特异性抗原（PSA）轻度下降。术后6个月MRI提示前列腺明显缩小，PSA明显下降，未见明显复发征象。术后无尿道坏死、尿道狭窄、尿道直肠瘘发生。1例患者随访6个月时因其他原因死亡。结论 MRI在评价氩氦刀低温冷冻治疗前列腺癌消融范围、术后复发或转移等疗效方面具有较好的临床应用价值。
목적：탐토MRI재아양도냉동치료전렬선암술후료효평개중적개치。방법계통회고2012년3월—2014년10월16례초성인도하아양도냉동치료전렬선암적림상급영상자료，분석술전술후실험실지표적변화，대비술전술후 MRI 자료，관찰소융효과，포괄유무술후잔류、전이등。결과술후1개월MRI 제시소유환자냉동소융범위만의，균표현위장T2신호，DWI급DCE-MRI미견명현이상복발，전렬선특이성항원（PSA）경도하강。술후6개월MRI제시전렬선명현축소，PSA명현하강，미견명현복발정상。술후무뇨도배사、뇨도협착、뇨도직장루발생。1례환자수방6개월시인기타원인사망。결론 MRI재평개아양도저온냉동치료전렬선암소융범위、술후복발혹전이등료효방면구유교호적림상응용개치。
Objective To evaluate MRI in judging the therapeutic effect of argon-helium cryoablation therapy for prostate cancer. Methods The clinical data and imaging materials of 16 patients with prostate cancer , who had received ultrasound-guided argon-helium knife cryogenic treatment at authors ’ hospital during the period from March 2012 to Oct. 2014, were retrospectively and comprehensively analyzed. The preoperative and postoperative laboratory test results were compared with MRI findings, and the ablation effect was assessed, focusing on the surgical residue, metastasis, etc. Results One months after the surgery, MRI demonstrated that satisfactory ablation extent was obtained in all patients, the ablated tumor tissue was characterized by long-T2 signal and no obvious recurrence could be found on DWI and DCE-MRI. A slight decrease of PSA level was observed. Six months after the surgery, MRI revealed that the prostate size was significantly reduced, PSA level was markedly decreased and no obvious evidence of recurrence was observed. No severe postoperative complications, such as urethral necrosis, urethral stricture or urethro-rectal fistula, occurred. During the 6-month following-up time, one patient died from other causes. Conclusion MRI has excellent clinical application value in estimating the ablation extent and in judging postoperative recurrence or metastasis of prostate cancer after argon-helium cryoablation treatment.