CAJ | 학술논문

目的：从医学检验的角度，提供血瘀证（BSS ）诊断的实验依据。以及进一步分析中医血瘀证辨证分型中的气虚血瘀证、气滞血瘀证、寒凝血瘀证与相关临床检验指标之间的相关性。方法选择中医气虚血瘀证、气滞血瘀证、寒凝血瘀证和健康人（健康组）各50例，采集血液样本按规定进行血流变学指标、凝血指标、血脂指标以及内皮素（E T ）、一氧化氮（N O ）、心钠素（ANP）、血清游离钙（F‐Ca2＋）、C反应蛋白（CRP）检测。结果三型血瘀证与健康组相比，血流变学指标、血脂指标以及ET、NO、ANP、CRP差异有统计学意义（P＜0．05）；气滞血瘀证与气虚血瘀证患者比较，血流变学指标（血浆黏度除外）、血脂指标以及ET、NO、ANP、CRP差异具有统计学意义（P＜0．05）；寒凝血瘀证与气虚血瘀证患者比较，血流变学指标、凝血指标、血脂指标以及ET、NO、ANP、F‐Ca2＋、CRP差异具有统计学意义（P＜0．05）；寒凝血瘀证与气滞血瘀证患者比较，血流变学指标、凝血指标、血脂指标以及ET、NO、ANP、F‐Ca2＋、CRP差异具有统计学意义（P＜0．05）。结论研究显示临床检验指标对气虚血瘀证、气滞血瘀证、寒凝血瘀证诊断分型提供实验依据，提高血瘀证诊断分型的客观性。为现代科学促进中医诊断学的发展提供了一种新的思路和方法。
목적：종의학검험적각도，제공혈어증（BSS ）진단적실험의거。이급진일보분석중의혈어증변증분형중적기허혈어증、기체혈어증、한응혈어증여상관림상검험지표지간적상관성。방법선택중의기허혈어증、기체혈어증、한응혈어증화건강인（건강조）각50례，채집혈액양본안규정진행혈류변학지표、응혈지표、혈지지표이급내피소（E T ）、일양화담（N O ）、심납소（ANP）、혈청유리개（F‐Ca2＋）、C반응단백（CRP）검측。결과삼형혈어증여건강조상비，혈류변학지표、혈지지표이급ET、NO、ANP、CRP차이유통계학의의（P＜0．05）；기체혈어증여기허혈어증환자비교，혈류변학지표（혈장점도제외）、혈지지표이급ET、NO、ANP、CRP차이구유통계학의의（P＜0．05）；한응혈어증여기허혈어증환자비교，혈류변학지표、응혈지표、혈지지표이급ET、NO、ANP、F‐Ca2＋、CRP차이구유통계학의의（P＜0．05）；한응혈어증여기체혈어증환자비교，혈류변학지표、응혈지표、혈지지표이급ET、NO、ANP、F‐Ca2＋、CRP차이구유통계학의의（P＜0．05）。결론연구현시림상검험지표대기허혈어증、기체혈어증、한응혈어증진단분형제공실험의거，제고혈어증진단분형적객관성。위현대과학촉진중의진단학적발전제공료일충신적사로화방법。
Objective To provide diagnostic basis for blood stasis syndrome (BSS) ,from the point of laboratory medical science . And to further analysis the correlation between qi deficiency and blood stasis ,qi stagnation and blood stasis ,cold coagulation and blood stasis syndrome with clinical testing indicators .Methods Chinese medicine qi deficiency and blood stasis ,qi stagnation and blood stasis ,cold coagulation and blood stasis syndrome and healthy (healthy group) 50 cases each were analyzed .Blood samples were collected ,Hemorheological indexes ,coagulation indexes ,blood‐lipoid indexes and endothelin (ET ) ,nitric oxide (NO ) ,atrial natriuretic peptide (ANP) ,serum free calcium (F‐Ca2+ ) ,C‐reactive protein (CRP) were tested .Results Compared with the healthy ,the results of hemorheological indexes ,blood‐lipoid indexes ,ET ,NO ,ANP ,F‐Ca2+ ,CRP of three types of blood stasis syn‐drome group were different significantly(P<0 .05) .qi deficiency and blood stasis group and qi stagnation and blood stasis group were compared ,the difference of hemorheological indexes (except plasma viscosity ) ,blood‐lipoid indexes ,and ET ,NO ,ANP ,CRP was statistically significant(P<0 .05) .Cold coagulation and blood stasis syndrome group and qi deficiency and blood stasis group were compared ,the difference of hemorheological indexes ,coagulation indexes ,blood‐lipoid indexes ,and ET ,NO ,ANP ,CRP was statistically significant (P<0 .05) .Cold coagulation and blood stasis syndrome group and qi stagnation and blood stasis group were compared ,the difference of hemorheological indexes ,coagulation indexes ,blood‐lipoid indexes ,and ET ,NO ,ANP ,CRP was statisti‐cally significant (P<0 .05) .Conclusion Study shows that clinical laboratory test index provide the experimental basis for the diag‐nosis of qi deficiency and blood stasis ,qi stagnation and blood stasis ,cold coagulation and blood stasis syndrome .Improve the objec‐tivity of classification of blood stasis syndrome .To provide a new way of for the development of modern science in promoting tradi‐tional Chinese medicine diagnostics .