CAJ | 학술논문

目的：探讨河源地区健康成年人血清中N端脑钠肽前体（N‐proBNP）水平分布情况及正常参考范围的初步调查。方法选取2010年11月至2012年11月在该院体检中心体格检查、实验室各项指标、心电图、B超检查均无异常的健康人群1017名，按性别和年龄的不同分为6个年龄组，A组为小于25岁、B组为25～＜35岁、C组为35～＜45岁、D组为45～＜55岁、E组为55～＜65岁、F组为大于或等于65岁。采用罗氏化学发光仪测定血清中N‐proBN P水平。结果年龄、性别均可以影响N‐proBNP水平的分布，且随着年龄的增加呈上升趋势，相邻各年龄组间（F组除外）血清N‐proBNP水平比较，差异有统计学意义（P＜0．05）；F组与各年龄组比较明显升高，差异有统计学意义（P＜0．05）；同组不同性别血清 N‐proBNP水平比较，差异有统计学意义（P＜0．05）。结论年龄、性别等生理因素均可以影响 N‐proBNP水平的分布，应根据不同年龄、性别设立相应的参考范围，为相关疾病的诊疗提供相应参数。
목적：탐토하원지구건강성년인혈청중N단뇌납태전체（N‐proBNP）수평분포정황급정상삼고범위적초보조사。방법선취2010년11월지2012년11월재해원체검중심체격검사、실험실각항지표、심전도、B초검사균무이상적건강인군1017명，안성별화년령적불동분위6개년령조，A조위소우25세、B조위25～＜35세、C조위35～＜45세、D조위45～＜55세、E조위55～＜65세、F조위대우혹등우65세。채용라씨화학발광의측정혈청중N‐proBN P수평。결과년령、성별균가이영향N‐proBNP수평적분포，차수착년령적증가정상승추세，상린각년령조간（F조제외）혈청N‐proBNP수평비교，차이유통계학의의（P＜0．05）；F조여각년령조비교명현승고，차이유통계학의의（P＜0．05）；동조불동성별혈청 N‐proBNP수평비교，차이유통계학의의（P＜0．05）。결론년령、성별등생리인소균가이영향 N‐proBNP수평적분포，응근거불동년령、성별설립상응적삼고범위，위상관질병적진료제공상응삼수。
Objective To investigate the healthy adults in Heyuan area of serum N terminal pro brain natriuretic peptide (N‐proBNP) concentration distribution and the preliminary investigation on the normal reference range .Methods From 2010 Novem‐ber to 2012 November in the physical examination ,laboratory examination center of our hospital indicators ,ECG ,B ultrasound ex‐amination showed no abnormalities of the healthy people 1 017 ,according to the different gender and age :A group less than 25 years ,group B was 25- <35 years ,35- <45 years ,group C ,group D 45- <55 years ,55- <65 years of E group ,F group for over 65 years a total of 6 age groups ,content determination of serum N‐proBNP by Roche chemical instrument light .Results age ,gen‐der can affect the distribution of N‐proBNP level ,and with the increase of age ,adjacent to the age groups (except F group) to com‐pare the serum levels of N‐proBNP ,the difference was statistically significant (P<0 .05);Compared with the F group in each age group was significantly increased(P<0 .05) ,there was statistical significance compared with the group ;the serum N‐proBNP level of different sex ,the difference was statistically significant (P<0 .05) .Conclusion age ,gender and other physiological factors can affect the distribution of N‐proBNP levels ,should establish the corresponding reference interval according to the different age ,gen‐der ,provide the corresponding parameters for the diagnosis and treatment of related diseases .