CAJ | 학술논문

目的：探讨白血病FAB分型与免疫分型的关系，以指导临床分析与治疗。方法回顾性分析2011～2013年该院收治462例初诊为各种类型白血病患者的临床资料，统计FAB分型及组化染色结果，部分患者进行流式细胞术（FCM ）免疫分型，并对两种检查结果进行分析比较。结果462例白血病患者中 FAB初诊急性髓细胞白血病（AML）171例，急性淋巴细胞白血病（ALL）50例，慢性白血病76例，少见类型3例，分型不明确56例，分型不符27例。FAB分型与临床诊断符合率82．03％；34例白血病行免疫分型，单表型29例，双表型4例，未表型1例，免疫分型与临床诊断符合率达到97．06％。髓系抗原CD13，CD33阳性表达率高；CD34及HLA‐DR在M3中未表达；CD7为髓系常伴随的淋巴系统表面抗原。结论免疫分型诊断准确率高于FAB分型，二者结合可提高诊断准确率，免疫分型在鉴别AML 各亚型具有重要作用。
목적：탐토백혈병FAB분형여면역분형적관계，이지도림상분석여치료。방법회고성분석2011～2013년해원수치462례초진위각충류형백혈병환자적림상자료，통계FAB분형급조화염색결과，부분환자진행류식세포술（FCM ）면역분형，병대량충검사결과진행분석비교。결과462례백혈병환자중 FAB초진급성수세포백혈병（AML）171례，급성림파세포백혈병（ALL）50례，만성백혈병76례，소견류형3례，분형불명학56례，분형불부27례。FAB분형여림상진단부합솔82．03％；34례백혈병행면역분형，단표형29례，쌍표형4례，미표형1례，면역분형여림상진단부합솔체도97．06％。수계항원CD13，CD33양성표체솔고；CD34급HLA‐DR재M3중미표체；CD7위수계상반수적림파계통표면항원。결론면역분형진단준학솔고우FAB분형，이자결합가제고진단준학솔，면역분형재감별AML 각아형구유중요작용。
Objective To study the relationship between FAB‐classifying standard and immunophenotype of leukemia in clinical diagnostic and treatment .Methods There were 462 cases of leukemia according to FAB‐classifying standard and 34 cases by immu‐nophenotype in our hospital from 2011 to 2013 .The results of FAB‐classifying standard and immunophenotype were statisticed and compared .Results Among the 462 cases ,there were 171 acute myeloid leukemia (AML) ,50 acute lymphoblastic leukemia (ALL) , 76 chronic leukemia ,3 rare types ,56 unclear types and 27 mismatched according the FAB‐classifying standard .The diagnostic rate was 82 .03% .34 cases of immunophenotype included 29 single phenotype ,4 double phenotypes and 1 unknown .The diagnosis rate was 97 .06% .CD13 and CD33 have high positive express in AML ;CD34 and HLA‐DR do not express in M3 ;CD7 which was known as a lymphatic antigen also was founded in AML .Conclusion The combing use of FAB‐classifying standard and immunophenotype can improve diagnostic rate ,and immunophenotype has an important role in differentiating different subtypes of leukemia .