CAJ | 학술논문

目的：观察消化道恶性肿瘤患者血浆血管性血友病因子（vWF）、抗凝血酶（AT ）、D‐二聚体（DD）及全血组织因子促凝活性（T F‐PC A ）检测结果并进行比较。方法使用仪器法对50例消化道恶性肿瘤转移患者（C组）及59例消化道恶性肿瘤未转移患者（B组）的vWF、AT、DD和TF‐PCA进行检测，并与60例健康体检者（A组）进行比较。结果与A组比较，B、C两组患者vWF、DD和TF‐PCA水平明显增高（P＜0．05），AT 显著降低（P＜0．05）；C组较B组vWF、DD和 TF‐PCA 水平增高（P＜0．05），AT水平降低（P＜0．05）；B组及C组内各种疾病之间比较，差异无统计学意义（P＞0．05）。结论消化道恶性肿瘤患者存在凝血及纤溶机制失衡，且转移较未转移消化道恶性肿瘤更加明显；其患者血栓前状态只与消化道恶性肿瘤本身有关，与肿瘤发生的消化道部位无明显关系。检测消化道恶性肿瘤患者vWF、AT、DD及TF‐PCA水平，可为其病情监测和预后提供参考。
목적：관찰소화도악성종류환자혈장혈관성혈우병인자（vWF）、항응혈매（AT ）、D‐이취체（DD）급전혈조직인자촉응활성（T F‐PC A ）검측결과병진행비교。방법사용의기법대50례소화도악성종류전이환자（C조）급59례소화도악성종류미전이환자（B조）적vWF、AT、DD화TF‐PCA진행검측，병여60례건강체검자（A조）진행비교。결과여A조비교，B、C량조환자vWF、DD화TF‐PCA수평명현증고（P＜0．05），AT 현저강저（P＜0．05）；C조교B조vWF、DD화 TF‐PCA 수평증고（P＜0．05），AT수평강저（P＜0．05）；B조급C조내각충질병지간비교，차이무통계학의의（P＞0．05）。결론소화도악성종류환자존재응혈급섬용궤제실형，차전이교미전이소화도악성종류경가명현；기환자혈전전상태지여소화도악성종류본신유관，여종류발생적소화도부위무명현관계。검측소화도악성종류환자vWF、AT、DD급TF‐PCA수평，가위기병정감측화예후제공삼고。
Objective To observe the levels of von willebrand factor (vWF) ,antithrombin (AT) ,D‐dimer (DD) and tissue fac‐tor procoagulant activity (TF‐PCA) on patients with malignant gastrointestinal tumor and then make comparisons .Methods Use machine to detect the vWF、AT、DD and TF‐PCA levels of 50 patients with metastatic gastrointestinal malignant tumor (group C) and another 59 patients with non‐metastatic gastrointestinal malignant tumor (group B) ,and then compare them with those 60 cases of normal physical examination people (group A) .Results Compared with group A ,the levels of vWF、DD and TF‐PCA showed obvious increases (P<0 .05) and the level of AT showed a significant decrease (P<0 .05) in group B and C .The levels of vWF、DD and TF‐PCA in group C were higher than those of group B (P< 0 .05) ,but the AT level showed an opposite change (P<0 .05) .Those comparisons of levels between different diseases in group B and C had no significant difference (P>0 .05) .Conclusion Patients with malignant gastrointestinal tumor have imbalance in coagulation and fibrinolysis system ,and this imbalance is much more obvious in metastatic tumor than non‐metastatic tumor .The prethrombotic state indexes of patients are only correlated to gas‐trointestinal malignant tumor ,but not to the parts where the tumor is in .Therefore ,the detection of vWF、AT、DD and TF‐PCA lev‐els can provide reference for the condition monitoring and prognosis of gastrointestinal malignant tumor .