CAJ | 학술논문

目的：分析近3年皮肤软组织感染（SSTIs）中金黄色葡萄球菌（SAU）的分离率、临床分布和药物敏感率，为临床诊治提供参考。方法选取该院2011年9月至2014年8月临床送检的SSTIs标本分离出的214例SAU。应用Whonet5．6软件进行统计分析。结果2152例感染脓性分泌物标本中，阳性标本1228例，其中SAU214例，占17．43％，耐甲氧西林金黄色葡萄球菌（MRSA）48例，占所有SAU的22．43％；主要分布在骨外科、烧伤整形科、乳腺外科、皮肤科，分别为40．2％、22．3％、12．1％、8．4％；对青霉素、红霉素及克林霉素的耐药率分别为96．3％，46．7％，37．4％，对万古霉素、利奈唑胺、呋西地酸、莫匹罗星有较高的敏感度。结论对于SSTIs该院外科感染率较高，临床上应按照SAU的药敏分析结果选择敏感度较高的第一、二代头孢菌素进行治疗，而万古霉素、利奈唑胺只有在严重SAU（包括MRSA）感染时才选用。
목적：분석근3년피부연조직감염（SSTIs）중금황색포도구균（SAU）적분리솔、림상분포화약물민감솔，위림상진치제공삼고。방법선취해원2011년9월지2014년8월림상송검적SSTIs표본분리출적214례SAU。응용Whonet5．6연건진행통계분석。결과2152례감염농성분비물표본중，양성표본1228례，기중SAU214례，점17．43％，내갑양서림금황색포도구균（MRSA）48례，점소유SAU적22．43％；주요분포재골외과、소상정형과、유선외과、피부과，분별위40．2％、22．3％、12．1％、8．4％；대청매소、홍매소급극림매소적내약솔분별위96．3％，46．7％，37．4％，대만고매소、리내서알、부서지산、막필라성유교고적민감도。결론대우SSTIs해원외과감염솔교고，림상상응안조SAU적약민분석결과선택민감도교고적제일、이대두포균소진행치료，이만고매소、리내서알지유재엄중SAU（포괄MRSA）감염시재선용。
Objective To investigate the separation rate ,clinical distribution ,antibiotic susceptibility rate of Staphylococcus au‐reus from skin and soft tissue infections and provide the reference for clinical diagnosis and treatment .Methods Retrospective sta‐tistical analysis of 214 strains of Staphylococcus aureus from skin and soft tissue infections from September 2011 to August 2014 by Whonet 5 .6 .Results 1 228 pathogens were isolated from 2 152 cases of the secretion of operative and skin wound ,of which there were 214 strains of Staphylococcus aureus ,which accounted for 17 .43% ,48 strains of MRSA ,which accounted for 22 .43% ;Mainly distributed in bone surgery ,burns orthopaedic ,breast surgery ,with skin venereal division ,accounting for 40 .2% ,22 .3% ,12 .1% , 8 .4% respectively .The resistance rate of Staphylococcus aureus to penicillin ,erythromycin ,clindamycin were 96 .3% ,46 .7% , 37 .4% respectively ,high sensitivity to vancomysin ,linezolid ,fusidic acid ,mupirocin .Conclusion Surgical infection rates of SSTIs are high in our hospital .It should be according to SAU susceptibility analysis results to choose high sensitivity of the first and sec‐ond generation cephalosporins for treatment in clinic ,and vancomycin ,linezolid only in severe Staphylococcus aureus(including MR‐SA) infection to choose .