CAJ | 학술논문

肿瘤浸润与转移是胃癌的基本特征，也是引起晚期胃癌患者死亡的首要因素。上皮性钙粘蛋白（E?cadherin）在胃癌发生、发展过程中发挥着重要作用，其表达减少或缺失可诱导上皮间充质转化（ MET）的发生。深入研究E?cadherin与胃癌的关系将有助于了解胃癌浸润与转移调控机制，从而为胃癌的临床治疗提供新的理论依据。本文就 E?cadherin在胃癌浸润与转移中作用的研究进展作一综述。
종류침윤여전이시위암적기본특정，야시인기만기위암환자사망적수요인소。상피성개점단백（E?cadherin）재위암발생、발전과정중발휘착중요작용，기표체감소혹결실가유도상피간충질전화（ MET）적발생。심입연구E?cadherin여위암적관계장유조우료해위암침윤여전이조공궤제，종이위위암적림상치료제공신적이론의거。본문취 E?cadherin재위암침윤여전이중작용적연구진전작일종술。
Invasion and metastasis are the basic characteristic of gastric cancer, and as well as the main cause of death in gastric cancer patients. Epithelial cadherin( E?cadherin) plays an important role in the oncogenesis and development of gastric cancer. The decreased expression of E?cadherin can induce epithelial?mesenchymal transition(EMT).So it is very significant for the further study on the relationship between E?cadherin and gastric cancer. It may provide a new theoretical basis for the treatment of gastric canc?er. In this paper, we review the progression in E?cadherin for the invasion and metastasis of gastric cancer.