临床肿瘤学杂志
臨床腫瘤學雜誌
림상종류학잡지
CHINESE CLINICAL ONCOLOGY
2015年
6期
545-548
,共4页
软组织肿瘤%横纹肌肉瘤%免疫组织化学
軟組織腫瘤%橫紋肌肉瘤%免疫組織化學
연조직종류%횡문기육류%면역조직화학
Soft tissue neoplasms%Rhabdomyosarcoma%Immunohistochemistry
目的：探讨新疆儿童胚胎性横纹肌肉瘤（ ERMS）的临床病理及免疫组化特点。方法回顾性分析新疆维吾尔自治区人民医院病理科2008年1月至2014年12月存档的20例ERMS患儿的临床病理资料、组织学特点及免疫学表型。结果20例ERMS中男性11例，女性9例，发病年龄10个月～18岁，平均年龄6．4岁，85．0％的患儿在10岁前发病；以少数名族为主，其中维吾尔族12例，汉族5例，其他民族3例；原发部位包括头颈部10例、四肢3例、泌尿生殖系统3例、躯干2例、肺部及盆腔各1例，临床表现因发病部位不同而各异。20例 ERMS 中有1例为葡萄状亚型，肿瘤组织 Vimentin、Desmin、MyoD1、Myogenin及CD99的阳性率分别为100．0％、90．0％、55．0％、90．0％和50．0％。结论 ERMS好发于10岁以前的儿童，男性多见，多发生于头颈部位，临床表现因发病部位不同而各异，少数民族明显高于汉族，组织形态学及免疫组化对诊断ERMS有重要参考价值。
目的：探討新疆兒童胚胎性橫紋肌肉瘤（ ERMS）的臨床病理及免疫組化特點。方法迴顧性分析新疆維吾爾自治區人民醫院病理科2008年1月至2014年12月存檔的20例ERMS患兒的臨床病理資料、組織學特點及免疫學錶型。結果20例ERMS中男性11例，女性9例，髮病年齡10箇月～18歲，平均年齡6．4歲，85．0％的患兒在10歲前髮病；以少數名族為主，其中維吾爾族12例，漢族5例，其他民族3例；原髮部位包括頭頸部10例、四肢3例、泌尿生殖繫統3例、軀榦2例、肺部及盆腔各1例，臨床錶現因髮病部位不同而各異。20例 ERMS 中有1例為葡萄狀亞型，腫瘤組織 Vimentin、Desmin、MyoD1、Myogenin及CD99的暘性率分彆為100．0％、90．0％、55．0％、90．0％和50．0％。結論 ERMS好髮于10歲以前的兒童，男性多見，多髮生于頭頸部位，臨床錶現因髮病部位不同而各異，少數民族明顯高于漢族，組織形態學及免疫組化對診斷ERMS有重要參攷價值。
목적：탐토신강인동배태성횡문기육류（ ERMS）적림상병리급면역조화특점。방법회고성분석신강유오이자치구인민의원병이과2008년1월지2014년12월존당적20례ERMS환인적림상병리자료、조직학특점급면역학표형。결과20례ERMS중남성11례，녀성9례，발병년령10개월～18세，평균년령6．4세，85．0％적환인재10세전발병；이소수명족위주，기중유오이족12례，한족5례，기타민족3례；원발부위포괄두경부10례、사지3례、비뇨생식계통3례、구간2례、폐부급분강각1례，림상표현인발병부위불동이각이。20례 ERMS 중유1례위포도상아형，종류조직 Vimentin、Desmin、MyoD1、Myogenin급CD99적양성솔분별위100．0％、90．0％、55．0％、90．0％화50．0％。결론 ERMS호발우10세이전적인동，남성다견，다발생우두경부위，림상표현인발병부위불동이각이，소수민족명현고우한족，조직형태학급면역조화대진단ERMS유중요삼고개치。
Objective To analyze the clinicopathological and immunohistochemical characteristics of pediatric embryonal rhabdomyosarcoma ( ERMS) in Xinjiang. Methods In this retrospective study, the clinical data and immunological phenotype of 20 cases of childhood ERMS were analyzed. Results There were 11 male and 9 female patients with ages ranging from 10 months to 18 years ( mean age:6. 4 years) , among which 85. 0% occur in children under the age of 10. There were 5 cases of the Han nationality, 12 cases of the Uyghur nationality and 3 cases of other ethnic nationalities. The primary sites were found in head and neck ( 10 cases) , extremities (3 cases), genitourinary system (3 cases), trunk (2 cases), lung (1 case) and pelvic (1 case) region. Clinical symp?toms varied widely, based on the location of the primary tumor. There was one case of botryoid rhabdomyosarcoma among 20 ERMS. The positive staining rates for Vimentin, Desmin, MyoD1, Myogenin and CD99 were 100. 0%, 90. 0%, 55. 0%, 90. 0% and 50. 0%, respectively. Conclusion ERMS was male?predominant and more common among children under 10 years old. It mainly occurs in head and neck region. The clinical manifestation is different depending on the different regions. The incidence of the minority nationality was significantly higher than that of the Han nationality. Morphology and immunohistochemical staining are very useful in the diagnosis of ERMS.
