CAJ | 학술논문

目的：探讨氩氦刀冷冻消融联合经肝动脉化疗栓塞（ TACE）治疗巨大肝癌的有效性和安全性。方法回顾性分析本院2006年9月至2011年8月收治的巨大肝癌患者85例，其中观察组44例先行1～2次TACE，1个月后序贯氩氦刀治疗1～3次，而对照组41例仅行单纯TACE治疗。按照实体瘤的疗效评价标准（ RECIST）1．0版评价疗效并随访生存。结果观察组有效率（ RR）为70．5％，高于对照组的46．3％（ P＜0．05）；观察组1、2和3年生存率分别为77．3％、56．8％和36．4％，中位生存时间为19．2个月，均高于对照组的51．2％、36．6％、14．6％和11．8个月（ P＜0．05）；两组患者的不良反应均为轻中度且可耐受。结论氩氦刀联合TACE治疗具有互补增效作用，且安全微创，为巨大肝癌的综合治疗提供了新的途径。
목적：탐토아양도냉동소융연합경간동맥화료전새（ TACE）치료거대간암적유효성화안전성。방법회고성분석본원2006년9월지2011년8월수치적거대간암환자85례，기중관찰조44례선행1～2차TACE，1개월후서관아양도치료1～3차，이대조조41례부행단순TACE치료。안조실체류적료효평개표준（ RECIST）1．0판평개료효병수방생존。결과관찰조유효솔（ RR）위70．5％，고우대조조적46．3％（ P＜0．05）；관찰조1、2화3년생존솔분별위77．3％、56．8％화36．4％，중위생존시간위19．2개월，균고우대조조적51．2％、36．6％、14．6％화11．8개월（ P＜0．05）；량조환자적불량반응균위경중도차가내수。결론아양도연합TACE치료구유호보증효작용，차안전미창，위거대간암적종합치료제공료신적도경。
Objective To explore the efficacy and safety of argon?helium knife cryotherapy combined with transcatheter arte?rial chemoembolization ( TACE) on huge hepatocellular carcinoma. Methods Eighty?five patients with huge liver cancer from Septem?ber 2006 to August 2011 were analyzed retrospectively. Observation group ( n=44) received one to two TACE and one to three argon?helium knife cryotherapy after one month sequently, while the control group ( n=41) received TACE treatment only. Response to chemotherapy was assessed by RECIST criteria 1. 0 and follow?up data was investigated. Results The response rate of observation group was 70. 5%, higher than 46. 3% of the control group (P<0. 05). The 1?, 2?, 3?year survival rates of observation group were 77. 3%, 56. 8% and 36. 4%, and medium overall survival time was 19. 2 months, which were all higher than the 51. 2%, 36. 6%, 14. 6% and 11. 8 months of control group ( P<0. 05) . The adverse reaction of both groups were mild?to?moderate and tolerable. Con?clusion Argon?helium knife cryotherapy combined with TACE has synergism effect and minimally invasive, and provide a new regiem for comprehensive treatment on huge hepatocellular carcinoma.