CAJ | 학술논문

目的：探讨C反应蛋白（ CRP ）与胃癌腹腔转移及预后的相关性。方法回顾性分析2008年6月至2014年8月于本院接受一线化疗的晚期胃癌患者150例，根据腹腔转移情况分为腹腔转移组（112例）和非腹腔转移组（38例），单因素和多因素分析年龄、性别、腹腔转移、CRP、白蛋白、ECOG评分对预后的影响，并比较腹腔转移组与非腹腔转移组的CRP、白蛋白和ECOG评分。结果单因素生存分析发现CRP、ECOG评分、白蛋白和腹腔转移与患者预后有关，而性别和年龄与预后无关。多因素生存分析发现腹腔转移是影响胃癌预后的独立因素（ P＜0．001）。与非腹腔转移组比较，腹腔转移组CRP、ECOG评分升高，而血浆白蛋白降低，差异均有统计学意义（ P＜0．05）。结论与非腹腔转移患者比较，胃癌腹腔转移患者预后较差，系统性炎症明显增强，应从炎症角度为胃癌腹腔转移患者提供治疗策略。
목적：탐토C반응단백（ CRP ）여위암복강전이급예후적상관성。방법회고성분석2008년6월지2014년8월우본원접수일선화료적만기위암환자150례，근거복강전이정황분위복강전이조（112례）화비복강전이조（38례），단인소화다인소분석년령、성별、복강전이、CRP、백단백、ECOG평분대예후적영향，병비교복강전이조여비복강전이조적CRP、백단백화ECOG평분。결과단인소생존분석발현CRP、ECOG평분、백단백화복강전이여환자예후유관，이성별화년령여예후무관。다인소생존분석발현복강전이시영향위암예후적독립인소（ P＜0．001）。여비복강전이조비교，복강전이조CRP、ECOG평분승고，이혈장백단백강저，차이균유통계학의의（ P＜0．05）。결론여비복강전이환자비교，위암복강전이환자예후교차，계통성염증명현증강，응종염증각도위위암복강전이환자제공치료책략。
Objective To explore the relationship of C?reactive protein ( CRP ) with peritoneal cavity metastasis and prognosis of gastric carcinoma. Methods In a retrospective study, the clinic data of 150 patients with advanced gastric carcinoma trea?ted with first?line chemotherapy, including 112 patients with peritoneal cavity metastasis and 38 patients with non?peritoneal cavity me?tastasis, was analyzed. Influences of CRP, serum albumin, Eastern Cooperative Oncology Group performance status ( ECOG PS) and peritoneal cavity metastasis on the prognosis were studied by univariate analysis and Cox proportional hazard mode. The difference of CRP, serum albumin and ECOG was analyzed between patients with or without peritoneal cavity metastasis. Results The results of univariate analysis showed that the factors associated with poor prognosis were CRP, serum albumin, ECOG and peritoneal cavity me?tastasis. According to multivariate analysis, peritoneal cavity metastasis was the only factor independently associated with prognosis. Compared with non?peritoneal cavity metastasis group, CRP ( P=0. 006) and ECOG PS ( P<0. 001) were significantly increased, while serum albumin group(P<0. 001) was significantly decreased in peritoneal cavity metastasis group(P<0. 001). Conclusion Compared with non?peritoneal cavity metastasis group, response of systemic inflammation was significantly upregulated in peritoneal cavity metastasis group with poorer prognosis, which could provide a treatment strategy for advanced gastric carcinoma patients with per?itoneal cavity metastasis from standpoint of inflammation.