临床与实验病理学杂志
臨床與實驗病理學雜誌
림상여실험병이학잡지
CHINESE JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
2015年
6期
662-665
,共4页
吴燕妮%何燕%李南云%吴波
吳燕妮%何燕%李南雲%吳波
오연니%하연%리남운%오파
垂体细胞瘤%免疫组织化学%预后
垂體細胞瘤%免疫組織化學%預後
수체세포류%면역조직화학%예후
pituicytoma%immunohistochemistry%prognosis
目的:探讨垂体细胞瘤的临床病理学特征。方法回顾性分析10例垂体细胞瘤的临床病理资料,并复习相关文献。结果10例患者中男性4例,女性6例,年龄4~68岁。肿瘤由伸长的双极梭形细胞构成,肿瘤细胞表达S-100(10/10)、vimentin (10/10)、GFAP(10/10)、EMA(4/10),不表达CKpan,Ki-67增殖指数1%~5%。随访9例患者,均存活,其中1例女性患者术后2年复发。结论垂体细胞瘤是一种低级别、好发于鞍区的梭形细胞肿瘤,成人多见,肿瘤易与毛细胞星形细胞瘤、神经垂体颗粒细胞瘤等混淆,免疫组化标记有助于鉴别诊断。手术完整切除预后良好,不完全切除者有复发可能。
目的:探討垂體細胞瘤的臨床病理學特徵。方法迴顧性分析10例垂體細胞瘤的臨床病理資料,併複習相關文獻。結果10例患者中男性4例,女性6例,年齡4~68歲。腫瘤由伸長的雙極梭形細胞構成,腫瘤細胞錶達S-100(10/10)、vimentin (10/10)、GFAP(10/10)、EMA(4/10),不錶達CKpan,Ki-67增殖指數1%~5%。隨訪9例患者,均存活,其中1例女性患者術後2年複髮。結論垂體細胞瘤是一種低級彆、好髮于鞍區的梭形細胞腫瘤,成人多見,腫瘤易與毛細胞星形細胞瘤、神經垂體顆粒細胞瘤等混淆,免疫組化標記有助于鑒彆診斷。手術完整切除預後良好,不完全切除者有複髮可能。
목적:탐토수체세포류적림상병이학특정。방법회고성분석10례수체세포류적림상병리자료,병복습상관문헌。결과10례환자중남성4례,녀성6례,년령4~68세。종류유신장적쌍겁사형세포구성,종류세포표체S-100(10/10)、vimentin (10/10)、GFAP(10/10)、EMA(4/10),불표체CKpan,Ki-67증식지수1%~5%。수방9례환자,균존활,기중1례녀성환자술후2년복발。결론수체세포류시일충저급별、호발우안구적사형세포종류,성인다견,종류역여모세포성형세포류、신경수체과립세포류등혼효,면역조화표기유조우감별진단。수술완정절제예후량호,불완전절제자유복발가능。
Purpose To study the c1inica1 and patho1ogica1 features of pituicytoma. Methods Ten cases of pituicytoma were re-trieved. Their c1inicopatho1ogic and immunohistochemica1 features were studied,and the re1ated 1iterature was a1so reviewed. Results The 10 patients aged from 4 to 68 years,with 4 ma1es,and 6 fema1es. The fo11ow-up information of 9 cases was co11ected:a11 of them were survived,whi1e one fema1e recurred 2 years after operation. Histo1ogica11y,the tumor was composed of bipo1ar e1ongated spind1e ce11. Immunohistochemica11y,the tumor ce11s showed strong1y positive for S-100(10/10)and vimentin(10/10),whi1e weak or foca1 positive for GFAP(10/10)and EMA(4/10). CKpan was negative in a11 cases and Ki-67 pro1iferation index was 1ow(1% ~5%). Conclusion Pituicytoma is a 1ow-grade spind1e ce11 tumor,typica11y occurs in the se11ar region. It is most common1y found in adu1ts,especia11y in ado1escent patients. The tumor shou1d be distinguished from pi1ocytic astrocytoma and neurohypophysea1granu1ar ce11 tumor. Pituicytoma exhibits strong1y positive for S-100 and vimentin. Genera11y,this tumor behaves indo1ent1y,but some may re-cur.