CAJ | 학술논문

雌激素缺乏是导致骨质疏松的重要原因之一。雌激素治疗骨质疏松症的临床疗效已获得普遍认可，其抗骨质疏松的作用，主要是通过促进成骨细胞增殖而产生效应。关于雌激素促成骨细胞的增殖，区别于经典的核效应，由雌激素膜受体介导的非核效应已成为研究热点。然而目前成骨细胞中非核效应的信号转导机制尚存争议。非核效应在成骨细胞中具体通过何种路径如ERK／MAPK通路、PI3K／Akt通路、Ca2＋通路及新型雌激素受体GPER介导的信号通路产生效应尚无统一认识。故本文就目前已提出的非核效应信号转导途径学说及研究进展进行介绍。
자격소결핍시도치골질소송적중요원인지일。자격소치료골질소송증적림상료효이획득보편인가，기항골질소송적작용，주요시통과촉진성골세포증식이산생효응。관우자격소촉성골세포적증식，구별우경전적핵효응，유자격소막수체개도적비핵효응이성위연구열점。연이목전성골세포중비핵효응적신호전도궤제상존쟁의。비핵효응재성골세포중구체통과하충로경여ERK／MAPK통로、PI3K／Akt통로、Ca2＋통로급신형자격소수체GPER개도적신호통로산생효응상무통일인식。고본문취목전이제출적비핵효응신호전도도경학설급연구진전진행개소。
Estrogen deficiency is one of the important causes of osteoporosis .The curative effect of estrogen in the clinical treatment of osteoporosis has won the general recognition .Its anti-osteoporosis effect is mainly through the effect on osteoblast proliferation .Different from the classic nuclear effects , non-nuclear effect mediated by estrogen receptor becomes the hot topics currently in the contribution of estrogen to osteoblast proliferation.However , the signal pathway mechanism of non-nuclear effect in osteoblast is still controversial . The signal pathways include ERK/MAPK pathway , PI3K/Akt pathway , Ca2+pathway and a novel estrogen receptor signaling pathway mediated by GPER .There is not unified understanding in which is the right signal pathway that make non-nuclear effect in osteoblasts .Thus this paper introduces the signal transduction theories of non-nuclear effects and the research progress in recent years .