中国急救复苏与灾害医学杂志
中國急救複囌與災害醫學雜誌
중국급구복소여재해의학잡지
CHINA JOURNAL OF EMERGENCY RESUSCITATION AND DISASTER MEDICINE
2015年
5期
456-459
,共4页
糖尿病%乙肝相关性肝癌%相关性
糖尿病%乙肝相關性肝癌%相關性
당뇨병%을간상관성간암%상관성
Diabetes mellitus%Hepatitis B virus (HBV) related Hepatocellular carcinoma%Correlation
目的:探讨糖尿病与乙肝相关性肝癌的发生是否存在相关性。方法对武警总医院肝脏移植研究所2002年4月~2013年5月住院期间的1536例肝病患者进行回顾性分析,采用统计学单因素与多元逐步Logistic回归法进行相关性分析。结果1536例肝病患者中,良性肝病患者735例(47.9%),乙肝相关性肝癌患者801例(52.1%)。单因素分析显示糖尿病在乙肝相关性肝癌患者中的发病率(32.6%)明显高于良性肝病组(23.5%,P<0.01);COX回归多因素分析显示糖尿病(OR=1.425,P<0.05)、HBsAg阳性(OR=3.44,P<0.01)、年龄>50岁(OR=3.56,P<0.01)、BMI ≥25(OR=3.59,P<0.01)、CH≥3.38 mmol/L(OR=1.96,P<0.05)、和AFP≥400ng/ml(OR=31.01,P<0.01)是肝癌发生的独立风险因素。结论糖尿病可能是乙肝相关性肝癌发生的风险因素之一。
目的:探討糖尿病與乙肝相關性肝癌的髮生是否存在相關性。方法對武警總醫院肝髒移植研究所2002年4月~2013年5月住院期間的1536例肝病患者進行迴顧性分析,採用統計學單因素與多元逐步Logistic迴歸法進行相關性分析。結果1536例肝病患者中,良性肝病患者735例(47.9%),乙肝相關性肝癌患者801例(52.1%)。單因素分析顯示糖尿病在乙肝相關性肝癌患者中的髮病率(32.6%)明顯高于良性肝病組(23.5%,P<0.01);COX迴歸多因素分析顯示糖尿病(OR=1.425,P<0.05)、HBsAg暘性(OR=3.44,P<0.01)、年齡>50歲(OR=3.56,P<0.01)、BMI ≥25(OR=3.59,P<0.01)、CH≥3.38 mmol/L(OR=1.96,P<0.05)、和AFP≥400ng/ml(OR=31.01,P<0.01)是肝癌髮生的獨立風險因素。結論糖尿病可能是乙肝相關性肝癌髮生的風險因素之一。
목적:탐토당뇨병여을간상관성간암적발생시부존재상관성。방법대무경총의원간장이식연구소2002년4월~2013년5월주원기간적1536례간병환자진행회고성분석,채용통계학단인소여다원축보Logistic회귀법진행상관성분석。결과1536례간병환자중,량성간병환자735례(47.9%),을간상관성간암환자801례(52.1%)。단인소분석현시당뇨병재을간상관성간암환자중적발병솔(32.6%)명현고우량성간병조(23.5%,P<0.01);COX회귀다인소분석현시당뇨병(OR=1.425,P<0.05)、HBsAg양성(OR=3.44,P<0.01)、년령>50세(OR=3.56,P<0.01)、BMI ≥25(OR=3.59,P<0.01)、CH≥3.38 mmol/L(OR=1.96,P<0.05)、화AFP≥400ng/ml(OR=31.01,P<0.01)시간암발생적독립풍험인소。결론당뇨병가능시을간상관성간암발생적풍험인소지일。
Objective To analyze whether diabetes mellitus (DM) is related to the incidence of hepatitis B virus (HBV)-related Hepatocellular Carcinoma (HCC). Methods A retrospective analysis was conducted on a total of 1,536 liver disease caseswhich the patients were admitted at Organ Transplantation Institute of the General Hospital in between June 2002and May2013.The correlation between DM and HBV-related HCC was analysis with univariate analysis and COX multivariate regression analysis. Results Amongthe 1,536 patients with liver disease, there were 735 (47.9%) patients withbenign liver disease and 801 (52.1 %) patients with HBV-related HCC. On univariate analysis, the incidence of DM in HCC patients (32.6%) was higher than that in patients of benign liver disease (23.5%) (P=0.000). On COX multivariate regression analysis, DM(OR=1.425, P<0.05), HBsAg (OR=3.44,P<0.01), age >50 years old (OR=3.56,P=0.000), body mass index (BMI) ≥25 (OR=3.59,P<0.01), cholesterol (CH) level H≥3.38 mmol/L (OR=1.96,P<0.05) and serum α-fetoprotein (AFP) level≥400 ng/mL (OR=31.01,P<0.01) were all significantly independent risk factor of the incidence of HCC. Conclusion DM may be a risk factor of the incidence of HBV-related HCC.