CAJ | 학술논문

目的：本研究旨在探讨银屑平颗粒的止痒作用。方法取豚鼠50只，按体重随机分为空白对照组、银屑平颗粒低、中、高剂量组、阳性对照药银屑灵组。记录每只豚鼠所给予组胺的总量，以此总量为致痒阈，并比较各组动物的致痒阈。结果银屑平颗粒高、中、低剂量组及阳性对照药银屑灵组可明显提高磷酸组胺致豚鼠局部瘙痒反应的致痒阈，与空白对照组比较差异有统计学意义（P<0.05）。结论银屑平颗粒能有效的抑制磷酸组胺引起的皮肤瘙痒，表明银屑平颗粒具有明显的止痒作用。
목적：본연구지재탐토은설평과립적지양작용。방법취돈서50지，안체중수궤분위공백대조조、은설평과립저、중、고제량조、양성대조약은설령조。기록매지돈서소급여조알적총량，이차총량위치양역，병비교각조동물적치양역。결과은설평과립고、중、저제량조급양성대조약은설령조가명현제고린산조알치돈서국부소양반응적치양역，여공백대조조비교차이유통계학의의（P<0.05）。결론은설평과립능유효적억제린산조알인기적피부소양，표명은설평과립구유명현적지양작용。
Objective To explore Yinxieping granules’Itching relief effect. Methods 50 cavies were randomly divided into control group, high dosage Yinxieping granules group, medium dosage group, low dosage group, and group of positive control drug of Yinxieling group based on their body weight. The total volume of histamine phosphate given to each cavy was recorded when the cavy turned its head to lick the affected foot, and this volume was taken as the threshold of itching and were compared among various groups. Results The threshold of itching of cavy model caused by histamine phosphate were largely increased by the high dosage of Yinxieping granules, middle dosage, low dosage, and the positive control drug of Yinxieling. Significant differences were found when comparing with the control group (P<0.05). Conclusion Yinxieping granules is considered being efficient in relieving itching caused by histamine phosphate, and reflected an obvious functionality of stopping the itch.