CAJ | 학술논문

目的：旨在探讨垂体后叶素( pituitrin )对感染性休克患者氧合功能的影响。方法对64例感染性休克患者在给予儿茶酚胺类药物提升血压基础上，随机分两组加用或不加用小剂量垂体后叶素（0.01~0.04u/h）治疗，比较两组间去甲肾上腺素剂量及氧合功能的差异。结果垂体后叶素组与对照组相比、前者去甲肾上腺素剂量减少（ug/min）（7.67±5.36、11.14±5.27，P=0.012），治疗24 h后前者氧合（PaO2/FiO2，mmHg）功能改善，统计学上显著高于后者（329.85±77.53、239±86.04，P=0.026）。结论垂体后叶素可减少去甲肾上腺素剂量，改善氧合作用。
목적：지재탐토수체후협소( pituitrin )대감염성휴극환자양합공능적영향。방법대64례감염성휴극환자재급여인다분알류약물제승혈압기출상，수궤분량조가용혹불가용소제량수체후협소（0.01~0.04u/h）치료，비교량조간거갑신상선소제량급양합공능적차이。결과수체후협소조여대조조상비、전자거갑신상선소제량감소（ug/min）（7.67±5.36、11.14±5.27，P=0.012），치료24 h후전자양합（PaO2/FiO2，mmHg）공능개선，통계학상현저고우후자（329.85±77.53、239±86.04，P=0.026）。결론수체후협소가감소거갑신상선소제량，개선양합작용。
Objective To evaluate the clinical effect of pituitrin for oxygenation of septic shock. Methods 64 patients with septic shock were randomly divided into two groups in a equal number, the pituitrin group and the control group. The pituitrin group was given pituttrin 0.01~0.04u/h while the contral group was treated with dopamine and/or norepinephrine (NE). Results The parameters of two groups were compared 24 hours after the treatment. NE dosage reflected low (ug/min), (7.67±5.36, 11.14±5.27, P=0.012) prior to the treatment. After the treatment, the pituitrin group’s oxygenation level improved significantly (PaO2/FiO2,mmHg), (329.85 ± 77.53, 239 ± 86.04, P =0.026). Conclusion Low-dose pituitrin combined with catecholamine is considered being effective in decreasing norephinephrine dosage and improving oxygenation level.