CAJ | 학술논문

高血压病人在未发生临床脑卒中之前，脑形态、功能以及脑网络已经产生了一定程度的损害，这些无症状的损害可引起认知能力的衰退。随着我国人口老龄化的加速，高血压患者的基数及其在人口中的比例也不断扩大，研究高血压（HTN）对人脑认知的影响是健康认知老化中的一个极其重要的问题。大脑年龄估值差（BrainAGE）被用于计算脑年龄与实际年龄的差别。118个对象（41个高血压患者）的磁共振图像首先通过图论分析，随后采用与年龄相关的脑网络拓扑特征来预测脑年龄。HTN的脑年龄比实际年龄高（4.1±3.1）岁，而健康对照组的脑年龄与实际年龄基本相符。BrainAGE可以作为一种临床生物标志物用来检测与HTN相关的脑异常老化模式。
고혈압병인재미발생림상뇌졸중지전，뇌형태、공능이급뇌망락이경산생료일정정도적손해，저사무증상적손해가인기인지능력적쇠퇴。수착아국인구노령화적가속，고혈압환자적기수급기재인구중적비례야불단확대，연구고혈압（HTN）대인뇌인지적영향시건강인지노화중적일개겁기중요적문제。대뇌년령고치차（BrainAGE）피용우계산뇌년령여실제년령적차별。118개대상（41개고혈압환자）적자공진도상수선통과도론분석，수후채용여년령상관적뇌망락탁복특정래예측뇌년령。HTN적뇌년령비실제년령고（4.1±3.1）세，이건강대조조적뇌년령여실제년령기본상부。BrainAGE가이작위일충림상생물표지물용래검측여HTN상관적뇌이상노화모식。
Long before patients in clinical stroke, hypertension (HTN) has caused a certain degree of damage on brain morphology, cognitive function and network. These asymptomatic damages can cause cognitive decline in function. With the acceleration of China’s aging population, cardinality and the proportion of the patients with HTN continues to expand. And the impact of HTN on the human brain becomes an important issue of healthy cognitive aging. The “Brain Age Gap Estimation” (BrainAGE) score was used to calculate the difference between the estimated brain age and chronological age. Analysis of 118 subjects (41 with HTN)’s MRI were ifrstly made using the graph theory. Then the brain age was estimated based on topological properties related to the age. The estimated brain age of HTN subjects in HTN Group was (4.1 ± 3.1) years greater than their chronological age, whereas the BrainAGE in Control Group was close to the chronological age. In summary, the BrainAGE may serve as a clinically relevant bio-marker to reveal the abnormal brain aging associated with HTN.