CAJ | 학술논문

目的：探讨AECOPD患者严重级别与血清CA125浓度间的相互关系。方法纳入AECOPD患者203例,健康对照组60例。根据AECOPD严重级别将患者分为轻度、中度、重度、极重度和危及生命5个亚组。比较AECOPD各亚组和健康对照组血清CA125的变化规律及相关关系。结果 AECOPD患者血清CA125浓度高于健康对照组,差异有统计学意义(P=0．000)。 AECOPD轻度和中度间CA125浓度差异无统计学意义(P=0．097),但随着病情恶化,CA125浓度升高明显。呼吸衰竭较无呼吸衰竭的AECOPD患者而言,血清CA125浓度的升高变化也有统计学意义(P=0．00)。有CO 2储留较无CO 2储留的AECOPD患者而言,血清CA125浓度显著升高,差异有统计学意义( P=0．00)。结论血清CA125浓度可能预测着AECOPD患者病情的变化,对其加强检测和应用,可能对AECOPD患者的管理有一定作用。
목적：탐토AECOPD환자엄중급별여혈청CA125농도간적상호관계。방법납입AECOPD환자203례,건강대조조60례。근거AECOPD엄중급별장환자분위경도、중도、중도、겁중도화위급생명5개아조。비교AECOPD각아조화건강대조조혈청CA125적변화규률급상관관계。결과 AECOPD환자혈청CA125농도고우건강대조조,차이유통계학의의(P=0．000)。 AECOPD경도화중도간CA125농도차이무통계학의의(P=0．097),단수착병정악화,CA125농도승고명현。호흡쇠갈교무호흡쇠갈적AECOPD환자이언,혈청CA125농도적승고변화야유통계학의의(P=0．00)。유CO 2저류교무CO 2저류적AECOPD환자이언,혈청CA125농도현저승고,차이유통계학의의( P=0．00)。결론혈청CA125농도가능예측착AECOPD환자병정적변화,대기가강검측화응용,가능대AECOPD환자적관리유일정작용。
Objective To explore the relationship between the severity of AECOPD with serum CA125 level. Methods According to the severity of AECOPD,two hundred and three AECOPD patients were divided into mild(n=45),moderate group (n=48),severe group(n=38),very severe group(n=35)and life-threatening group(n=17),sixty healthy subjects served as a normal group. The concentration of CA125 in the different groups were compared. Results The serum CA125 of AECOPD pa-tients was significantly higher than that in healthy control group,the difference was statistically significant(P=0. 000). No statistic difference of CA125 concentration between mild and moderate AECOPD patients(P=0. 097). But with the further aggravate the condition,the concentration of CA125 increased significantly. Respiratory failure than those without respiratory failure of AECOPD patients,the serum CA125 concentrations can lead to significant changes(P=0. 00). Carbon dioxide retention can lead CA125 el-evated significantly(P=0. 00). Conclusion The concentration of serum CA125 may be a powerful predictor of AECOPD. Self monitoring and management for AECOPD may improve cognitive impairment.